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12-11-2008, 02:23 PM | #1 | ||
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Senior Member
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Anyone see this headline about a PD vaccine in trials? They don't even know what causes this! Or maybe they are working backwards and this will help find cure for those already suffering? Here's the link:
http://www.marketwatch.com/news/stor...FF2A8E4D98E%7D |
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12-11-2008, 03:31 PM | #2 | |||
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In Remembrance
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First, they are betting that stopping alpha-synuclein is all it will take;
Second, they are saying there is no problem with inducing our immune system to attack a peptide that we produce. Third, there is this- 1: Acta Neuropathol. 2008 Apr;115(4):479-89. Epub 2008 Jan 10. Curcumin inhibits aggregation of alpha-synuclein. Pandey N, Strider J, Nolan WC, Yan SX, Galvin JE. Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA. Aggregation of amyloid-beta protein (Abeta) is a key pathogenic event in Alzheimer's disease (AD). Curcumin, a constituent of the Indian spice Turmeric is structurally similar to Congo Red and has been demonstrated to bind Abeta amyloid and prevent further oligomerization of Abeta monomers onto growing amyloid beta-sheets. Reasoning that oligomerization kinetics and mechanism of amyloid formation are similar in Parkinson's disease (PD) and AD, we investigated the effect of curcumin on alpha-synuclein (AS) protein aggregation. In vitro model of AS aggregation was developed by treatment of purified AS protein (wild-type) with 1 mM Fe3+ (Fenton reaction). It was observed that the addition of curcumin inhibited aggregation in a dose-dependent manner and increased AS solubility. The aggregation-inhibiting effect of curcumin was next investigated in cell culture utilizing catecholaminergic SH-SY5Y cell line. A model system was developed in which the red fluorescent protein (DsRed2) was fused with A53T mutant of AS and its aggregation examined under different concentrations of curcumin. To estimate aggregation in an unbiased manner, a protocol was developed in which the images were captured automatically through a high-throughput cell-based screening microscope. The obtained images were processed automatically for aggregates within a defined dimension of 1-6 microm. Greater than 32% decrease in mutant alpha-synuclein aggregation was observed within 48 h subsequent to curcumin addition. Our data suggest that curcumin inhibits AS oligomerization into higher molecular weight aggregates and therefore should be further explored as a potential therapeutic compound for PD and related disorders. PMID: 18189141 [PubMed - indexed for MEDLINE] Quote:
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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