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12-18-2008, 08:01 PM | #1 | |||
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Senior Member
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(Rick and Ron--think these researchers are reading your posts!)
Neuropathol Appl Neurobiol. 2008 Dec 11. [Epub ahead of print] Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases.Stolp H, Dziegielewska K. Department of Pharmacology, University of Melbourne, Parkville 3010, Australia. Abstract The causes of most neurological disorders are not fully understood. Inflammation and blood-brain barrier dysfunction appear to play major roles in the pathology of these diseases. Inflammatory insults that occur during brain development may have widespread effects later in life for a spectrum of neurological disorders. In this review a new hypothesis suggesting a mechanistic link between inflammation and blood-brain barrier function (integrity), which is universally important in both neurodevelopmental and neurodegerative diseases, is proposed. The role of inflammation and the blood-brain barrier will be discussed in cerebral palsy, schizophrenia, Parkinson's disease, Alzheimer's disease and multiple sclerosis, conditions where both inflammation and blood-brain barrier dysfunction occur either during initiation and/or progression of the disease. We suggest that breakdown of normal blood-brain barrier function resulting in a short-lasting influx of blood born molecules, in particular plasma proteins, may cause local damage such as reduction of brain white matter observed in some newborn babies, but may also be the mechanism behind some neurodegenerative diseases related to underlying brain damage and long-term changes in barrier properties. PMID: 19077110 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
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In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson |
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12-18-2008, 09:22 PM | #2 | |||
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In Remembrance
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But they still are missing three-quarters. If it was just this aspect there'd be a lot more PD etc. I just don't see how "they" can see PD as just a neurological problem and be blind to endocrine aspects and gastro too. At least these guys are picking up on some of the more interesting stuff.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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12-19-2008, 02:19 AM | #3 | |||
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In Remembrance
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No Rick, there is only a limited number ie those with neurological disease who have a dysfunctional BBB. It could be a genetic failing. Then anything that worsens the permeability, eg stress, promotes further deterioration, and anything that closes the permeability slows progrssion, eg curcumin.. I have given long lists of substances which have these effects in my many BBB threads.
I still don't see why research is not done to characterise the level of BBB permeability of PWP and compare them with healthy people. The technology exists to measure it on living people. The permeability increases with age of everyone, it could be used as a diagnostic test for impending PD. There must be a threshold above which the symptons of PD occur. Ron
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Diagnosed Nov 1991. Born 1936 |
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11-19-2009, 09:10 AM | #4 | |||
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Senior Member
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I AM BUMPING THIS THREAD UP (POSTED ABOUT A YEAR AG0).
WHAT HAVE WE DISCOVERED ON THIS PROMISING THEORY? PEG |
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11-19-2009, 12:07 PM | #5 | |||
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In Remembrance
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Hi Peg,
A few research groups have picked up on it, but very little work is being done compared to the millions being spent on stem cells and the rest. Maybe my post on "The Role of the BBB in PD" was a bit too long and boring. If anyone wants to be bored again, it is at http://neurotalk.psychcentral.com/sh...rier+Ronhutton and a follow up at, http://neurotalk.psychcentral.com/sh...rier+Ronhutton I can't understand why the topic is not investigated more. When I worked in research, the theory that answered the most questions was the front runner. The BBB theory answers the following. 1. Why is PD predominently an old persons disease? A. Because the BBB ages and becomes more porous with age. The threshold is passed beyond a certain permeability and you have PD 2 Why does stress accentuate symptoms? A Because stress has been shown to widen the BBB and a temporary surge of toxins can enter the brain. There is also the possibility that dopamine itself could leak out through the opened BBB into the bloodstream, robbing you of what little L-Dopa you have, and causing a freeze. 3. Why do the following chemicals cause an exacerbation of PD symptoms? Nitric oxide, carbon monoxide, organo phosphates (eg sheep dip), etc A Because they all widen the BBB permeability. 4 Why is curcumin, citicoline, alpha lipoic acid, GDNF, bilberry extract etc credited with improving symptoms A They all reduce the BBB permeability There are other examples, but above are the main ones. If the answer is not the BBB idea, then how else do you explain these facts. I am continuing to meet and correspond with academics, and I will keep pushing the idea. Ron
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Diagnosed Nov 1991. Born 1936 |
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"Thanks for this!" says: | Conductor71 (11-19-2009), lindylanka (11-19-2009), olsen (11-19-2009), Sasha (11-20-2009), violet green (11-19-2009) |
11-19-2009, 02:46 PM | #6 | |||
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In Remembrance
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Ron-
You might consider pointing out that theories of a role for inflammation/neuroinflammation automatically have to incorporate the BBB since these both increase permeability, i.e. no one can reasonably claim that it isn't the BBB, it's inflammation because they go hand-in-hand. A similar argument can be made for stress. Also, a leaky BBB is often accompanied by a "leaky gut" which allows more toxins to pass from the gut into the blood and then into the brain.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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"Thanks for this!" says: | olsen (11-19-2009) |
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