FAQ/Help |
Calendar |
Search |
Today's Posts |
11-24-2006, 11:56 PM | #1 | |||
|
||||
Senior Member
|
(further evidence for use of folic acid--CS mentioned in an earlier post that he uses folic acid supplementation. husband uses 800 mcg/day...)
New Role for Folic Acid in Parkinson's New research indicates the vitamin folic acid may protect against Parkinson's disease. Experiments conducted with mice—who closely resemble humans genetically—offer "the first direct evidence that folic acid may have a key role in protecting adult nerve cells against age-related disease," says Mark Mattson, chief of the neurosciences laboratory of the National Institute on Aging. The study findings were reported in the January Journal of Neurochemistry. Mice deprived of folic acid had fewer dopamine-producing cells, and more damaged cells, than mice given folic acid. Low levels of dopamine, a chemical in the brain that affects movement, are symptomatic of Parkinson's. The National Academy of Sciences recommends 400 micrograms daily of folic acid, which is found in many B-complex vitamins. |
|||
Reply With Quote |
11-25-2006, 12:57 AM | #2 | |||
|
||||
In Remembrance
|
Good one Olsen, I have had Folic acid in my list of supplements for years now. I know Jaye uses it too. It is one of those supplements that doesn't seem to do much, (you can stop it with no obvious difference). However, this reinforces my belief that it is an essential long term item in our portfolio.
Ron |
|||
Reply With Quote |
11-25-2006, 01:36 AM | #3 | ||
|
|||
Member
|
That is called a "vitamin" in this Folic acid (vitamin Bc, Vitamin M), Made in gobs by yeast fermentation. I just find out what would be considered "covered" by that vit per dayby 1, which is why you have to look long and dozingly into a 10 to the -2 or 10 to the 6th power dosages you are getting, from where, and don't spend your money on "useless perceived benefit supplement". Remember, it's your body (and it can pretty well tell your mind that what you've been consuming is or is not a "placebo")and your money, so if you just want the wildestly expensive s-- t in town then let others do the 'dosing for you"
There are a lot of benefits to taking supplements; benefits which we know that we know are good for us, should be taken in specified or unspecified anounts and times. Then there are suplements and vitamins that we know that we don't know are good for us, theses should not be taken at all or in unspecified amounts and times, then finally there are vitamins and supplements which we we don't know that are not good for us or not, so should be taken in moderation ,Rumsy you ol' blod clot you Supplementology is an art and must be careful to be the best kind of scientists, if there's bad prees (or good); take it all with a grain of salt, combine with a cup to a barrel of net-research, another pinch salt from your heart, an maybe you've got something, maybe you don't.cs |
||
Reply With Quote |
11-25-2006, 09:20 AM | #4 | ||
|
|||
ex Member
|
Folic acid is essential for the formation of L-dopa.
L-dopa is made in the dopaminergic neurons via the following means : L-tyrosine + THFA + O2 + Fe2+ → L-dopa + DHFA + H2O + Fe2+ In order to make L-dopa and what appears on the right hand side of the arrow : L-dopa + DHFA + H2O + Fe2+ You need to have what appears on the left hand side of the arrow, which includes THFA : L-tyrosine + THFA + O2 + Fe2+ THFA, which is essential for the formation of L-dopa is made from folic acid : Folic acid > DHFA > THFA The formation of L-dopa was proven to go up and down according to how much THFA was present, and the formation of THFA goes up or down (up to a limit) according to how much foilic acid somebody has. So by taking folic acid, somebody can help to increase their own L-dopa levels. |
||
Reply With Quote |
11-25-2006, 12:49 PM | #5 | |||
|
||||
In Remembrance
|
...
1: Ann Neurol. 2004 Aug;56(2):221-7. Folic acid supplementation enhances repair of the adult central nervous system. Iskandar BJ, Nelson A, Resnick D, Pate Skene JH, Gao P, Johnson C, Cook TD, Hariharan N. Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA. iskandar@neurosurg.wisc.edu Folic acid supplementation has proved to be extremely effective in reducing the occurrence of neural tube defects (NTDs) and other congenital abnormalities in humans, suggesting that folic acid can modulate key mechanisms for growth and differentiation in the central nervous system (CNS). To prevent NTDs, however, supplemental folate must be provided early in gestation. This suggests that the ability of folic acid to activate growth and differentiation mechanisms may be confined to the early embryonic period. Here, we show that folic acid can enhance growth and repair mechanisms even in the adult CNS. Using lesion models of CNS injury, we found that intraperitoneal treatment of adult rats with folic acid significantly improves the regrowth of sensory spinal axons into a grafted segment of peripheral nerve in vivo. Regrowth of retinal ganglion cell (RGC) axons into a similar graft also was enhanced, although to a smaller extent than spinal axons. Furthermore, folic acid supplementation enhances neurological recovery from a spinal cord contusion injury, showing its potential clinical impact. The results show that the effects of folic acid supplementation on CNS growth processes are not restricted to the embryonic period, but can also be effective for enhancing growth, repair, and recovery in the injured adult CNS. Copyright 2004 American Neurological Association PMID: 15293274 [PubMed - indexed for MEDLINE]
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
|||
Reply With Quote |
11-25-2006, 08:06 PM | #6 | |||
|
||||
Wisest Elder Ever
|
Currently there has been the discovery that some people do not methylate
folic acid to its active form well in vivo. The last I saw there are 25 separate genetic errors found so far with this. There is another form now, to bypass this problem.. And I suggest you all consider it. Methylfolate is available now, at inexpensive prices. And example is MetaFolin by Source Naturals. You can read more here: http://www.metafolin.com/pdfs/metafolin2004_merck.pdf Methylfolate is now included in some Rx versions of vitamins. Cerefolin and Metanx are examples. However you can buy it OTC in 800mcg (lower) doses. It is not expensive.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
|
|||
Reply With Quote |
Reply |
|
|
Similar Threads | ||||
Thread | Forum | |||
Neuroprotective Effect of Phytic Acid on Parkinson's Disease? | Parkinson's Disease | |||
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease. | Parkinson's Disease | |||
The role of a lifetime: Parkinson's | Parkinson's Disease | |||
Amino Acid -DLPA : for depression and pain - and Parkinson's Disease | Parkinson's Disease |