Parkinson's Disease Tulip

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Old 01-26-2009, 10:32 PM #1
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Arrow Disordered respiration as a levodopa-induced dyskinesia in Parkinson's disease

http://www3.interscience.wiley.com/j...13828/abstract


Disordered respiration as a levodopa-induced dyskinesia in Parkinson's disease


J.E. Rice, MBBS (Hons) 1, R. Antic, FRACP 2, Philip D. Thompson, PhD, FRACP 1 3 *
1Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia
2Thoracic Medicine Unit, Royal Adelaide Hospital, Adelaide, Australia
3University Department of Medicine, Royal Adelaide Hospital, Adelaide, Australia

email: Philip D. Thompson (philip.thompson@adelaide.edu.au)

*Correspondence to Philip D. Thompson, University Department of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, S. Australia 5000, Australia

Keywords
Parkinson's disease • L-dopa • respiratory dyskinesia


Abstract
Symptomatic respiratory disturbance as a consequence of levodopa (L-dopa) therapy for Parkinson's disease (PD) has been described only rarely and may be underrecognized in clinical practice. We report on two patients with PD in whom the introduction or augmentation of L-dopa therapy was associated with the development of irregular and rapid breathing. Analysis of breathing patterns before and after L-dopa demonstrated a striking change in respiratory rate after administration of L-dopa, with the emergence of irregular tachypnea alternating with brief periods of apnea, in a pattern consistent with a central origin. In both cases, the temporal relationship of the respiratory disturbance to the administration of L-dopa suggested a peak-dose drug effect. Previous reports of L-dopa-induced respiratory dyskinesia are reviewed, and the potential mechanisms whereby L-dopa might influence the central control of respiration to produce irregular breathing patterns are discussed.
2002 Movement Disorder Society
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Resolve to be tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant with the weak and the wrong. Sometime in your life you will have been all of these.
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Old 01-28-2009, 10:42 AM #2
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Thanks Tina,

It keeps adding up..........maybe 'they' (those in the know) were afraid to tell us in great detail. I would have fell off my chair and would have had to be carried out. Looking back now, of course I would have done everything I could to stay off L-dopa. All the folks I know personally, who seem to do well, follow this philosophy.

I stopped reducing my dopamine until I get my spine and pd symptoms analyzed, and sorted out or which is what? My legs shake violently for various lengths of time and I have neurological symptoms of nerve problems. This seems to be confusing and no one knows what to do with me. I get referred so often it is beginning to be a circle. I'm right back where I started from. I'm not kidding.

Sorry Tina, this has changed into my usual rant of late. For everyone's sake (my friends and family) I do hope I get the help I need soon.

Bonnie
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"Thanks for this!" says:
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Old 01-28-2009, 02:36 PM #3
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Heart dear bonnie,

I will pray for you - that doors open with cures / or miracles...
I have trouble getting a good breath sometimes, so hard to breathe
I lay across an ottoman (on my stomach with my knees on the floor and my head hanging over) hope you can picture what I am saying, cuz I can't photograph it / and wont...
this helps so I can stretch the abdominal muscles...
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with much love,
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.


.
by
.
, on Flickr
pd documentary - part 2 and 3

.


.


Resolve to be tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant with the weak and the wrong. Sometime in your life you will have been all of these.
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