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04-08-2009, 09:19 AM | #1 | ||
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Most PD patients start with an agonist and as their pd progresses add Levodopa.I was diagnosed 7 years ago at the age of 71 and started medicating with Levodopa.I am taking 300mg daily.Recently my symptoms have progressed,especially my rigidity.As the Levodopa causes a mild case of Dyskinesa,I prefer not to increase the Levodopa.From your experience ,would adding a agonist decrease ther rigidity?
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04-08-2009, 11:22 AM | #2 | |||
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In Remembrance
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I take sinemet and requip. 600 mg and 24 mg respectively. Lately I have been experimenting and find that requip greatly increases my own dyskinesia but that the sinemet is much smoother. Sinemet doses of 1200 mg are not unusual, so you have a high ceiling. And there is the age issue - at 59 I have to "pace" myself differently than you do at 78. Every new drug brings its own problems, too. Finally, Ldopa causes a certain amount of damage itself so I take alpha lipoic acid and acetyl-L-carnitine to counter some of that. Good luck.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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04-08-2009, 11:48 AM | #3 | ||
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As you are probably aware what works for some may not work for you. I too had increasing dyskinsia with requip, unable to titrate my levodopa down enough to get it right. Remember an agonist is supposed to kind of boost your levodopa effects. I had good results with comtan, a COMT inhibitor. It helps. the dopamine that you have (levodopa or otherwise) no be broken down as fast so it will last longer. I currently am taking 1 1/4 tablets, that difference in 1/4 and 1/2 are real but I didn't think so at first. Good luck.
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