Parkinson's Disease Tulip


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Old 07-03-2009, 08:47 AM #1
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Default Why so coy?

The following caught my eye this morning due to its mention of anti-inflammatory action. But it became more interesting as I realized that the "natural compound" was conspicuously never identified.

http://www.sciencedaily.com/releases...0702112842.htm

"ScienceDaily (July 3, 2009) — Researchers at the University of Oklahoma Health Sciences Center have found a way to use a natural compound to stop one of the leading causes of blindness in the United States. The research appears online this month in the journal Diabetes, a publication of the American Diabetes Association...."
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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Old 07-04-2009, 10:14 AM #2
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Default

Send them some money and you might find out what it is.

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Old 07-04-2009, 11:14 AM #3
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Lightbulb

it is angiostatin, and the K5 faction that was tested.
There are PubMed papers on this.

It is not a natural "supplement" which is one thinks of when
reading that paper.

http://en.wikipedia.org/wiki/Angiostatin
Quote:
Diabetes. 2009 Jun 2. [Epub ahead of print]Click here to read Links
Nanoparticle-mediated Expression of an Angiogenic Inhibitor Ameliorates Ischemia-induced Retinal Neovascularization and Diabetes-induced Retinal Vascular Leakage.
Park K, Chen Y, Hu Y, Mayo AS, Kompella UB, Longeras R, Ma JX.

Department of Medicine, Department of Cell Biology, University of Okalahoma Health Sciences Center, Oklahoma City, OK.

Objective: The objective of the present study is to evaluate the effect of nanoparticle-mediated gene delivery of angiogenic inhibitors on retinal inflammation, vascular leakage and neovascularization in diabetic retinopathy. Research design and methods: An expression plasmid of plasminogen kringle 5 (K5), a natural angiogenic inhibitor, was encapsulated with poly lactide-co-glycolide to form K5 nanoparticles (K5-NP). Expression of K5 was determined by Western blot analysis and immunohistochemistry. Retinal vascular leakage was measured by permeability assay. Retinal neovascularization was evaluated using fluorescein-angiography and counting pre-retinal vascular cells in rats with oxygen-induced retinopathy (OIR). Effects of K5-NP on retinal inflammation were evaluated in streptozotocin (STZ)-induced diabetic rats by leukostasis assay and Western blot analysis of ICAM and VEGF. Possible toxicities of K5-NP were evaluated using histology examination, retinal thickness measurement, and electroretinogram (ERG) recording. Results: K5-NP mediated efficient expression of K5 and specifically inhibited growth of endothelial cells. An intravitreal injection of K5-NP resulted in high-level expression of K5 in the inner retina of rats for the entire 4 weeks analyzed. Injection of K5-NP significantly reduced retinal vascular leakage and attenuated retinal neovascularization, when compared to the contralateral eyes injected with Control-NP in OIR rats. K5-NP attenuated VEGF and ICAM-1 over-expression, reduced leukostasis and vascular leakage for at least 4 weeks after a single injection in the retina of STZ-induced diabetic rats. No toxicities of K5-NP were detected to retinal structure and function. Conclusion: K5-NP mediates efficient and sustained K5 expression in the retina and has therapeutic potential for diabetic retinopathy.

PMID: 19491211 [PubMed - as supplied by publisher]

Related articles

* Plasminogen kringle 5 reduces vascular leakage in the retina in rat models of oxygen-induced retinopathy and diabetes.
from http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
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Old 07-06-2009, 07:40 PM #4
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Default I know this is not what this thread is about, but I just have to say something....

about Diabetic Induced Diseases.

As an insulin dependent diabetic myself...

The basic reason that diabetics lose their eyesight is due to glucose.
Why are the organs of the body effected by high glucose readings?

And this is preventable!!

First, the pancreas cannot make enough insulin to turn glucose into energy. The glucose builds up in the body and begins to coat the organs. It is this buildup that causes diabetic induced diseases of the organs.

"Long-term diabetes complications, which result from damage to the body's tissues. Persistent high blood sugar can damage the eyes (diabetic retinopathy), kidneys (diabetic nephropathy), nerves (diabetic neuropathy), heart (leading to a heart attack), and blood vessels (leading to strokes, peripheral arterial disease, and possibly amputation)."

Diabetic retinopathy is how I discovered I was diabetic. I estimate that I was diabetic for at least 10 years...when I look back pre-PD. I also wonder if it was a non-motor symptom of PD.

Gratefully, I was hospitalized with a glucose count of almost 700 and reversed all my diabetic symptoms then and there. Sadly though even while keeping my glucose in check over the years I have also gained too much weight. It is carbohydrates to count, but one can still lose it with calories.

I remember those hospital days. I remember the video I had to watch. I remember the nutritionist chatting with me.

Diabetic disease is preventable. But, controlling diabetes is a choice too many don't care to make. So, when you think I am just seeking attention or being ridiculous checking my glucose at a conference guys (say PAN Forum for example), this is the reason. I know I will "crash" and pass out at 70, and 150 is far too high for me. Over 150, which is not common, unless I am eating conference food!, then I have to use my "rescue" insulin.

What I DON'T remember is anyone ever SCARING me into submission during my initial hospitalization...telling me about the resulting disease(s), etc., if I don't maintain my glucose number to acceptable (between 70 and 130 mg/dl before meals, and less than 180 two hours after starting a meal) and keeping my A1c in an acceptable range (with a glycated hemoglobin level less than 7 percent)...my last A1c was 6.8, which is too high if you ask me...but my Internist told me "you made my day." She was referring to how so few of her diabetic patients pay NO attention to their diabetes and the numbers mean nothing to them.

Actually, today is the first day of my new vegetarian regime. I am using the McDougall free 12-Day program. If I had $5,000 for the class and airfare I would again attend his in-house 10 day program in California, but alas, I am now a very broke disabled person! I had the opportunity through my job to attend a week long class while I was still working (and be paid for the week too), but I failed to continue after the first month. I went on the road for work and restaurant eating was too irresistible!

Okay, so I am done .
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I long to accomplish a great and noble tasks, but it is my chief duty to accomplish humble tasks as though they were great and noble. The world is moved along, not only by the mighty shoves of its heroes, but also by the aggregate of the tiny pushes of each honest worker. ~~Helen Keller
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