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How Does Gabapentin Work?

 
 
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Old 09-01-2009, 10:17 AM #5
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
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Gabapentin and Lyrica are mysterious drugs. Basically the way they work is still not understood. But the general public does not know this:

http://en.wikipedia.org/wiki/Gabapentin

Quote:
Gabapentin was initially synthesized to mimic the chemical structure of the neurotransmitter gamma-aminobutyric acid (GABA), but is not believed to act on the same brain receptors.

Its exact mechanism of action is unknown, but its therapeutic action on neuropathic pain is thought to involve voltage-gated N-type calcium ion channels. It is thought to bind to the α2δ subunit (1 and 2)[2] of the voltage-dependent calcium channel in the central nervous system.[3]
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