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Old 09-02-2014, 03:38 PM #281
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1127 days sober.

I really don't have much to report.

95f here today in Central VA, sunny, low humidity. The earth is still round. Spent most of the day on the phone with various long-term rehab facilities finding a place for two who have fallen. Road trip tomorrow in the Benz!!

Stay strong!
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Old 09-04-2014, 06:12 PM #282
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Just checking in too with the totally random number of 814 days. What's less random is that (combined with quitting smoking) I have now saved over $20,000. Not that I really saved it (d'oh ) but that's the amount I didn't spend on my "vices". Not too shabby...
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Old 09-05-2014, 06:31 AM #283
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Quote:
Originally Posted by Wide-O View Post
I have now saved over $20,000.
I had to do the math too.

1130 days x ~$20 a day = $22,580 saved

That is almost enough to stop drinking without taking PN into account!!

LOL

I still smoke, about 3 packs a week (and steadily dropping), and when I am done with these then I will be able to afford another car

But, hey, one vice at a time!!!
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Old 09-10-2014, 02:25 AM #284
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Default Extreme pain in foot -spreading to hands .. Help !

Hi everyone ,
I am a 52 year old woman who used to have a 2 bottle of wine a day habit . I stopped for five months in 2013 but resumed little by little in 2014. Over the last two months I have had an EXCRUCIATING in my right foot and tingling/ twinges in my other foot and hands . I have had all the tests under the sun ( blood tests, brain and spine MRI, foot mri, nerve conduction tests ) and all were normal. The neurologist says he doesn't know what it is. The GP however is convinced it is related to my drinking .. And frankly, so am I . he says it is related to historical not current levels of alcohol consumption which have harmed my nerves . I am on Gabapentin which certainly calms the pain and Diclofenac . I have drunk wine sporadically over the last two months (c 10 days out of each month but binging on each occasion) . I realise now I need a loooong period without alcohol and in fact to stop completely . I am therefore on day 3 of no alcohol. I was wondering if this awful , frightening pain goes away and how long it takes . I am very scared. Is alcoholic neuropathy reversible ???
I look forward to hearing from you .
Take care
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Old 09-10-2014, 09:24 AM #285
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Short answer: maybe

Grab an ice tea, find a comfy chair and read through this whole thread, your answer will be in here somewhere.

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Old 09-10-2014, 12:37 PM #286
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Thank you Ice a House .. I have read through it a few times before I posted . I am so happy that you are felling better ! :-)
Can someone tell me the exact doses of B vitamins that help alcoholic neuropathy .. Do you still take them if you take benfotiamine ??
Thanks so much ,
S xx
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Old 09-12-2014, 07:34 AM #287
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Quote:
Originally Posted by Paininfoot View Post
Thank you Ice a House .. I have read through it a few times before I posted . I am so happy that you are felling better ! :-)
Can someone tell me the exact doses of B vitamins that help alcoholic neuropathy .. Do you still take them if you take benfotiamine ??
Thanks so much ,
S xx

You can see in the thread and elsewhere on the site the various doses and vitamins people have tried. Maybe Mrs. D has an update. I did just find this on PubMed. A few weeks ago, I posted that I believe methycobalamine (a form of B12, is helping me. Here is an abstract I just found. That is some heavy duty dosage they are using there, but apparently there are no adverse effects.

"Intern Med. 2014;53(17):1927-31. Epub 2014 Sep 1.
Safety and Efficacy of Intravenous Ultra-high Dose Methylcobalamin Treatment for Peripheral Neuropathy: A Phase I/II Open Label Clinical Trial.
Shibuya K1, Misawa S, Nasu S, Sekiguchi Y, Beppu M, Iwai Y, Mitsuma S, Isose S, Arimura K, Kaji R, Kuwabara S.
Author information
Abstract
Objective No clinically effective treatment for promoting peripheral axonal regeneration has yet been established. Several experimental studies in vitro and in vivo have shown that a high dose of methylcobalamin (MeCbl), an analogue of vitamin B12, promotes axonal growth in peripheral nerve injury. We herein assessed the safety and efficacy of an ultra-high dose MeCbl treatment for patients with peripheral neuropathy and chronic axonal degeneration. Methods Fourteen patients with immune-mediated or hereditary neuropathy in the chronic progressive or stable phase were enrolled. MeCbl, 25 mg/day for 10 days followed by monthly 25 mg for 5 months, was intravenously administered. The patients were evaluated before and 1 year following treatment. The primary endpoints were safety and improvement in the Medical Research Council (MRC) sum score in at least two muscles of the 20 muscles. This trial is registered with the University Hospital Medical Information Network (UMIN) Center in Japan under the ID: UMIN000009359. Results There were no adverse effects in twelve of the patients, whereas treatment was discontinued in two patients who had seborrheic dermatitis at 3 months and respiratory tract infection at 2 months, respectively. Therefore, twelve patients were evaluated for the primary outcomes; the MRC sum score was improved in seven of the patients and unchanged or worsened in the remaining five patients. Conclusion Intravenous ultra-high dose MeCbl treatment is a safe and potentially efficacious therapy for patients with peripheral neuropathy and chronic axonal degeneration.
PMID: 25175124 [PubMed - in process]

*here is the link http://www.ncbi.nlm.nih.gov/pubmed/25175124 *

Last edited by Chemar; 09-12-2014 at 04:00 PM. Reason: * adding required link
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Old 09-12-2014, 12:47 PM #288
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Quote:
Originally Posted by newstown View Post
You can see in the thread and elsewhere on the site the various doses and vitamins people have tried. Maybe Mrs. D has an update. I did just find this on PubMed. A few weeks ago, I posted that I believe methycobalamine (a form of B12, is helping me. Here is an abstract I just found. That is some heavy duty dosage they are using there, but apparently there are no adverse effects.

"Intern Med. 2014;53(17):1927-31. Epub 2014 Sep 1.
Safety and Efficacy of Intravenous Ultra-high Dose Methylcobalamin Treatment for Peripheral Neuropathy: A Phase I/II Open Label Clinical Trial.
Shibuya K1, Misawa S, Nasu S, Sekiguchi Y, Beppu M, Iwai Y, Mitsuma S, Isose S, Arimura K, Kaji R, Kuwabara S.
Author information
Abstract
Objective No clinically effective treatment for promoting peripheral axonal regeneration has yet been established. Several experimental studies in vitro and in vivo have shown that a high dose of methylcobalamin (MeCbl), an analogue of vitamin B12, promotes axonal growth in peripheral nerve injury. We herein assessed the safety and efficacy of an ultra-high dose MeCbl treatment for patients with peripheral neuropathy and chronic axonal degeneration. Methods Fourteen patients with immune-mediated or hereditary neuropathy in the chronic progressive or stable phase were enrolled. MeCbl, 25 mg/day for 10 days followed by monthly 25 mg for 5 months, was intravenously administered. The patients were evaluated before and 1 year following treatment. The primary endpoints were safety and improvement in the Medical Research Council (MRC) sum score in at least two muscles of the 20 muscles. This trial is registered with the University Hospital Medical Information Network (UMIN) Center in Japan under the ID: UMIN000009359. Results There were no adverse effects in twelve of the patients, whereas treatment was discontinued in two patients who had seborrheic dermatitis at 3 months and respiratory tract infection at 2 months, respectively. Therefore, twelve patients were evaluated for the primary outcomes; the MRC sum score was improved in seven of the patients and unchanged or worsened in the remaining five patients. Conclusion Intravenous ultra-high dose MeCbl treatment is a safe and potentially efficacious therapy for patients with peripheral neuropathy and chronic axonal degeneration.
PMID: 25175124 [PubMed - in process]
Wow, that IS a high dosage of MeCBL. Here I am, popping two chewables (under the tongue as suggested on the bottle), a few times a day, that are only 1000 mcg / 1 mg. And as Mrs.D suggested in earlier posts, I take them on an empty stomach whenever possible. But it's probably not doing much of anything at such a low dose!? And I see the vitamin was injected during this study. I am sitting here picturing myself taking half a bottle of this stuff for 10 days in pill form! Would appreciate your take on this, Mrs.D, whenever you can chime in. I am also on Benfotiamine (300mg 3x per day) and R-ALA (200mg 3x per day). And the standard adult multi-vitamin.
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Old 09-12-2014, 01:59 PM #289
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Japan has always been aggressive with B12 since their
Horrific epidemic of low B12 due to use of a toxic drug
For diarrhea in the early 1970's. They also had a study years
Ago for MS using about 40 mg a day oral.

Oral works for most people. You will get up to 13 mcg from
1000 mcg taken on an empty stomach. That is about 3 times
The RDA from food. Methyl form is preferred because there
Are many with the DNA mutation that prevents activation
To methyl form. There is no data yet on absorption from 5 mg
But i wouldn 't think it would be much over 20mcg.
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Old 09-13-2014, 05:05 PM #290
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Hi newstown
we have to abide by Internet copyright regulations and so it is really important that you please provide a link as well as the full citation (title and authors) whenever you do a snip quote and also remember that any site that has the COPYRIGHT or (c) or ALL RIGHTS RESERVED allows *no* copy /pasting...so you can only link to them

Please could you provide the link and the citation for the quote in your post before mine

thanks
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