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Magnate
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--there are a number of other immunological tests that can be done, based on the type of neuropathy one has, that look for specific antibodies to components of peripheral nerve.
The most common tests that are done are thsoe for anti-MAG (myelin associated glycoprotein) antibodies; these are common in certain demyelinating sensory syndromes. One also is usally tested for the sulfated glycoprotein (SPGP) as well. Then, there are tests for the anti-sulfatide antibody (often found in syndromes with sensory loss or dysthetic symptoms), and others for specific components of nerve, labelled GM1 (this one is found in many motor syndromes), GD1a and GD1b (mixed sensory-motor syndromes), GQ1b (Miller-Fisher and other neuro-ophthalmologic syndromes), anti-Tubulin (soemtimes found in chronic demyelinating neuropathies), some other antibodies associated with vasculitis or ANA, such as c-ANCA and p-ANCA, and those associated with paraneoplastic syndromes (anti-Hu, anti-Yo, anti-Ri). You can see this gets complicated. Very few centers have the capacity to run all these tests. Many neuros don't even know of the existence of some of them. It's why places like Cornell-Weill, Hopkins, Mayo, and the Jack Miller Center are so valuable--much of the research on these autoantibodies stems from these centers. LizaJane has all these on her charts, as well as some more associated with attacks on other organs (such as the pancreas and thyroid gland). Here's a good paper that describes blood/serum tests for neuropathy: http://www.questdiagnostics.com/hcp/...eralNeurop.htm |
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