NeuroTalk Support Groups - Rosacea and PN...

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It is hard to say how much Metronidazole would be absorbed.
The gel would facilitate it, I'd imagine.

I don't think enough would be systemic to be a factor, but, you never know with drugs:

Quote:

Pharmacokinetics

Topical administration of a one gram dose of METROGEL® (metronidazole gel), 1% to the face of 13 patients with moderate to severe rosacea once daily for 7 days resulted in a mean±SD Cmax of metronidazole of 32±9 ng/mL. The mean±SD AUC(0-24) was 595±154 ng*hr/mL. The mean Cmax and AUC(0-24) are less than 1% of the value reported for a single 250 mg oral dose of metronidazole. The time to maximum plasma concentration (Tmax) was 6-10 hours after topical application.

http://www.rxlist.com/metrogel-drug.htm

Notice only 13 patients tested.

Hi
What do you do about the roscasca in your eyes? Eye doc wrote a script for Pataday, stops the itching for a while, but it always comes back the next day. I don't have many eye lashes left because of this! LOL

Barb, because my rosacea has been so sporadic over the years, I actually am not treating it with any medications and I never have. Just when it is about to drive me to the doctors, it settles down. My sister has it too and it affects her the same way...

Quote:

Originally Posted by mrsD (Post 593769)

It is hard to say how much Metronidazole would be absorbed.
The gel would facilitate it, I'd imagine.

I don't think enough would be systemic to be a factor, but, you never know with drugs:

http://www.rxlist.com/metrogel-drug.htm

Notice only 13 patients tested.

The number of patients is typical of these companies. I'm amazed that the FDA approves these drugs with studies that small:rolleyes:. I think I'm going to stop using it and go back to using the lotion I purchased that is an alternative type of treatment called Prosacea along with Eucerin and/or Cetaphil.

As for the other posts concerning eyes, I use artificial tears to help prevent the crusting which occurs as a result of Rosacea and to keep the eyes hydrated. In the winter, I use the gel form at bedtime since using heat dries the eyes and I find that the dryness aggravates the Rosacea. I use them as often as needed and this was suggested by my opthalmologist. The dermatologist has also prescribed doxycycline at times when its gotten out of hand but I find that I haven't had to use those when I regularly use drops/gels. Take care.

I developed a rash as well. It looked very similar to a Lupus rash execept it went into the folds of my nose/lip area as well as the usual malar rash area. It got horrible when I went off meds! Then it calmed down when I got off everything.....made me wonder if drug induced Lupus was going on?? They list drugs that cause lupus, however, there are many more.

I also took doxycycline.....not good with Lupus...and not good with sunshine!

Oh I also got big brown spots that are fading away now.

Makes ya wonder!