I decided to go forward with the lumbar decompression surgery, which I had done on 11/30. It was a 2 level decompression done at L3-4 and 4-5.

As I have mentioned earlier, I had this done because 3 doctors told me I needed it and because the neurosurgeon here in Atlanta who did it was almost completely convinced that it would relieve the PN which I have had in my feet for the last 8-10 years. He said that the compression at the 2 levels was very, very severe.

In addition, the doctor I visited at Johns Hopkins discovered that my B6 level was very high and instructed me to stop all B6 supplements, which I have done (starting about 3 weeks ago).

So far, which has been about 16 days, I have not experienced any relief with the PN in my feet. The neurosurgeon said that it is way too early for that.

I am wondering if the compression was truly causing my problem, how long should it be before I notice any changes/relief? Everything I have read on the forum previously leads me to believe that it does take quite some time for the healing process.

I would love to hear your honest opinions regarding my situation. Thanks so much.

As far as the B-6, mine was also high--47.4, reference range 5-30. I had small fiber sensory neuropathy in my feet, legs and hands. I also had electric shock sensations in my arms. Two weeks after stopping B-6 supplements, symptoms subsided. The numbness has taken several months to resolve. Unlike your situation, I have an underlying neuropathy that complicates matters, possibly mild CMT. I hope, once you stop the B-6, things will improve.

I think it is definitely a wait and see thing, and individual cases vary in their results. My mother had a trapped nerve in her neck released, but did not experience any improvement in pain. She still has it (the pain) over 10 years later.

That doesn't mean that your pain won't improve, as I think individual cases vary a lot. Got my fingers and toes crossed for you

Raglet

I would think at least 3-6 mos, if not longer - for
injured nerves (trapped) to heal. Sometimes it can take
3 or 4 years to recover at least 75%-85% of prior state.
Injured nerves are very slow to regenerate.
When they do, it is possible that new pathways are grown, to bypass any that may not heal properly.
Expecting 100% recovery may be setting the bar a bit high.
Check about supplements to help improve
the healing process (esp B12).

Regarding blood levels of B6:

1) Studies have shown that in autistic patients, B6 can be elevated when NO vitamins are used.
2) also there is a factitious (false positive) for potassium. If the tourniquet is on too tightly, or the blood sample is handled wrong, the red cells can burst and release their potassium to give a higher than normal level, in the serum which is what is tested. I am wondering if this can happen with B6 which is inside red blood cells.
http://www.ajcn.org/cgi/content/abstract/50/5/1059
If the red cells break open during the blood draw or later due to poor handling, there could be a false positive high reading.
The only way to test this is to redo the test, and not use any supplement of any kind for many weeks before the blood sample is taken. If it remains high for no reason, that indicates either it is not being used by the body properly ..activated to pyridoxal, or is somehow a factitious reading.
I searched the net this morning again, and this question comes up on many other sites, and the typical answer, is "don't know".

If you stop all B6 and still have neuro symptoms, and a high reading in the blood serum, I'd consider using activated B6 called P5P. B6 is unusual because deficiency and excess gives similar symptoms, and this is very difficult to evaluate, if the testing procedure may be flawed.

Mrs. D, I was recently diagnosed with PN and I wanted to ask you about B6. I had been taking one multivitamin with 3 mg of B6, 2 calcium citrate supplements with 10 mg/tablet and one B50 supplement (periodically). Total B6 intake from supplements was 73 mg. My pyridoxine level was 47.4 ng/ml (ref range 5.0-30.0). I had significant peripheral neuropathy symptoms at that level. I stopped the B6 and most symptoms subsided within a couple of weeks. My current B6 level is 5.0 ng/ml and I am taking no supplements. I should add I still have an underlying mild neuropathy which my neurologist suspects is CMT. I don't have any neuropathic pain, just some spotty numbness in the feet. Everything I have read says I should be okay taking up to 100 mg of B6. Why am I different? I'd like to take some B6 just to get a little higher in the normal range. Do you recommend the P5P? By the way, I am a 60 year old male, otherwise in good health, very physically active.