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Cymbalta - how long to take effect?

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Old 12-19-2009, 10:55 PM #1
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Hi all and thanks again for helping me figure out how far I wanted to go with finding a cause of my PN. I've pretty much accepted that I will probably never know and need to deal with managing the pain.

I have been taking Gabapentin and Ultram, which hasn't controlled the pain as much as I'd like. So I'm now trying Cymbalta and Ultram. The neuro said that it can take up to a few months for Cymbalta to really work for this type of application. If Cymbalta had worked for any of you, did you find that it took that long or did it kick in much sooner? I have my doubts about this particular neuro's knowledge in this area because he gave me a puzzled look when I said something about the Cymbalta/Ultram cocktail (he was going to prescribe only Cymbalta). I thought that the cocktail approach was pretty well known with PN.
Hi Joan, just chiming in to add that neurontin did not help me, admitedly very low dose, due to side effects. Cymbalta helped within a couple weeks. Hate the thirsty, dry mouth side effect. But worth the trade off for me. And I only had to take 30mg a day to get benefits. Extended my length of standing to about 30 min. errands, etc...

Best Wishes TT
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Old 12-19-2009, 11:26 PM #2
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In a previous post on this website, someone had seen Dr. Latov (peripheral neuropathy book author/neurologist) who said Cymbalta has a synergestic effect with Gabapentin.
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Old 12-21-2009, 04:37 PM #3
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Personally I think amitriptyline is a better choice. It shows benefits for peripheral neuropathy healing...that no other drug shares. (this is fairly new). But that is only my opinion.
That's really interesting, mrsD! I'll have to ask my neuro about that.

Update: I've been feeling significantly better the last few days. I occasionally have a not-too-bad day, but never a string of good days in a row like this. I've been on the Cybalta for about three weeks now.

I hate to get my hopes up so soon, but it's hard not to. If it's really helping, maybe I could even taper off of the Ultram. I'll keep you all posted.

Thanks!
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Old 12-29-2009, 03:16 PM #4
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Hmm...posted a few hours ago to give an update (I thought) but now I don't see it. Maybe I clicked the wrong button or...? Anyway, I said before that I'm not sure now if the Cymbalta is helping or not. I've had several good days and several bad days so it's hard to tell overall. I probably should have rated my pain every day when I started this med so I could compare, but I guess if you're not sure, it's probably not helping all that much. Still, like I said, I don't usually have more than one good day in a row so maybe it is helping some.

I started yesterday on the dose my neuro wanted me to get up to (90mg) so I'll just have to wait to see for the next week or two. At least I don't seem to be having any side effects so at least there's that to be happy about.
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