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-   -   Skyn Biopsy (https://www.neurotalk.org/peripheral-neuropathy/110975-skyn-biopsy.html)

JoshuaY46012 12-28-2009 01:56 PM

Quote:

Originally Posted by filipe (Post 604444)
Hope to hear from you :) Can one assume with a normal EMG and a normal skin biopsy that he doesn't have NP?
Is a skin biopsy an effective way to evaluate if your nerves are regenerating?

If you have a prior Skin Biopsy to compare it to.

With a Normal EMG and Normal Skin Biopsy, I would start look elsewhere for answers, maybe a Central Problem. Your symptoms don't sound like Small Fiber to me anyways.

filipe 12-28-2009 02:06 PM

Thank you Joshua. You were the only one that answered me directly to my questions, and I was so stupid not to pay attention to them in the first place. I was so stress out that I answered without reading your message. I feel that, maybe MRI irrritated my peripherical nerves somehow and now my nerves are regenerating. Or maybe as you said this is from my head. If MRIs did something permenant to one's body I would be the first case in history, right? What realy messes with my head is that there are times that I'm fine and in the following moment I feel so bad. I'm also having difficulty quiting Diazepan. Everytime I reduce it i feel more pain. I don't know if this is because I'm so afffraid of quiting them.

JoshuaY46012 12-28-2009 02:16 PM

Quote:

Originally Posted by filipe (Post 604447)
Thank you Joshua. You were the only one that answered me directly to my questions, and I was so stupid not to pay attention to them in the first place. I was so stress out that I answered without reading your message. I feel that, maybe MRI irrritated my peripherical nerves somehow and now my nerves are regenerating. Or maybe as you said this is from my head. If MRIs did something permenant to one's body I would be the first case in history, right? What realy messes with my head is that there are times that I'm fine and in the following moment I feel so bad. I'm also having difficulty quiting Diazepan. Everytime I reduce it i feel more pain. I don't know if this is because I'm so afffraid of quiting them.

I think the pain is from quitting Valium. It will be painful, it could cause you to feel very sick. That isn't due to neuropathy, that's due to that medication.

cyclelops 12-28-2009 04:24 PM

You can't just quit diazepam, you have to wean. And yes, ALL benzodiazepines cause this syndrome when you quit, even if it was a low dose taken as prescribed for less than a month.

Docs don't tell you that after about 3 weeks, you will have withdrawal when you get off, and also, prepare to be quite ill for at least 2 weeks coming off of this garbage. Two weeks after your last dose, you are thru the worst. Three to six months out, you may start to feel normal.

Nothing mitigates it....nothing. It is like labor and delivery, you just have to get thru it. Maybe being a woman makes me very frank about this. You just have to endure it. Talk to your doctor about cutting down the drug and how to do it. I bet you will feel better after you wean off. But like I said, it is a rough road for two weeks after your last dose. Weaning isn't fun either.

Check out the websites, there is benzobuddies, and benzowithdrawal and a few others. Some have live chat to help you thru the bad times.

You were not injured by the MRI, but you are causing 'kindling' of your nervous system with interdose withdrawal. It will make withdrawal worse if you continue this.

mrsD 12-28-2009 04:27 PM

If you recall Filipe, I gave you a website that discusses how to taper off this drug, in PMs a little while ago.

It could be that your use of this drug is creating many problems for you.

This has to be done slowly, over quite a bit of time. People vary in easily they can discontinue benzos like Valium.

glenntaj 12-29-2009 07:07 AM

And just to make some comments about skin biopsy--
 
--just because one's intraepidermal nerve fiber density falls between the 5th and 95th percentile, and is therefore read acccording to the protocols as "normal", doesn't mean one doesn't have a neuropathic process going on, It depends on when the skin biopsy is done--at what stage the process may have been "caught"--and, of course, at what level of density one started (though this is hard to know, since there's no reason to do this kind of biopsy to enumerate nerve density and examine condition if one is asymptomatic, unless, like McArthur's original subjects, there's an attempt to establish a control group).

Pain levels do not correlate well at all to density levels; there may be a bit more correlation to observed condition of the fibers, especially if swelling an excessive branching of individual fibers is observed (and yes, the latter is an attempt to re-establish function in areas in which nerves are under attack, so it can be a hint there is an attack ongoing when found). Remember, regrowing nerves can be as painful as dying ones, at least for a while, until the brain learns how to interpret these new signals.

My sense has been that often pain is actually worse during an ongoing process; if one's nerves are completely killed off, one tends to get more numbness than pain, as there's less there to record sensations anymore. Of course, many have reported both in an area simultaneously--certain patches have died, certain patches are dying, certain others may be frantically trying to re-grow. In fact, many neuros take the sharp, burning pain as a sign of damaged nerves, not (yet) dead ones, and actually look upon this with a more favorable prognosis than they do numbness, though I doubt the patients find this "better".

filipe 12-29-2009 08:25 AM

Hi Cyclops,

But you also think I don't have NP, right? Do you think it might be my brain that is perpetuating the pain? When I begin feeling pain again, it is in the right same spot where I felt before and after the MRI. The pain is a mixture ff burn and cold sensations. Yesterday night I try to take half a pill (of 5 mg Diazepan) and I awake in the middle of the night I thougt about Diazepan and I start feeling pain. I also feel pain when I rubb my body on stuff, is it consistent with NP?

PS: My wife is very concerned about me and she is going to put some threads. There are in my profile but they are sign by her. She will be the one that is going to read all the answears. She made me promisse I don't see the answers myself. This is realy a life drama. Sorry guys.

filipe 12-29-2009 08:52 AM

Tell me Glenntage, how long do Small Nerve fibers take to regenerate? Can you tell me if after its regeneration has finished the pain stops? This is my most important question so far in this forum. I don't mind waiting, 1, 2 or 10 years. I just want to be sure there is a valid reason for my pain and that the pain stops when my nerves heal and regenerate. And they do regenerate, right?

There was a Dr that told me that NP is chronic in some cases because nerves are destroyd faster than they regenerate. Is this true?

Thank you very much,

Filipe

cyclelops 12-29-2009 09:00 AM

Filipe I don't think you have had the proper diagnosis.

I don't think that any one here can help you beyond what we have done.

JoshuaY46012 12-29-2009 01:38 PM

Quote:

Originally Posted by filipe (Post 604653)
Tell me Glenntage, how long do Small Nerve fibers take to regenerate? Can you tell me if after its regeneration has finished the pain stops? This is my most important question so far in this forum. I don't mind waiting, 1, 2 or 10 years. I just want to be sure there is a valid reason for my pain and that the pain stops when my nerves heal and regenerate. And they do regenerate, right?

There was a Dr that told me that NP is chronic in some cases because nerves are destroyd faster than they regenerate. Is this true?

Thank you very much,

Filipe


Why don't you re-read this thread.

http://neurotalk.psychcentral.com/thread43699.html you've posted there, i'm sure you've read enough to know that they do heal themselves over time.


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