I have noticed no symptoms especially when taking supplements that increase IGF-1 and/or growth hormone. In fact, I have been taking Colostrum from Symbiotics and have found better sleep and feeling pretty vigorous. Colostrum is what mamma cows give to their young to stimulate fast growth. It strengthens the immune system as well. This supplement is all natural, no Rbst. Wondering how much the hormonal connection has been explored? Especially poor Adrenal Function and Low Testosterone? I know alot of the tests conventional medicine gives you are weak detectors at best.