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Too much serotonin is the issue. Where there is too much action on those receptors serious things can go wrong.
Normally we all have serotonin working for us. There are many types of receptors too, located all over the body. But when you add drugs into the picture, this sensitive system can get overloaded. And it varies from person to person too. Some people just normally live with high serotonin levels, and those types would be more prone to serotonin syndrome. It is thought for example, psychologically that timid or careful people are high serotonin expressors. Contrasted with high dopamine people who are drawn to excitement and risk taking activities. You won't find many high serotonin types sky diving, for example!;) Those with high serotonin systems, often get the worst side effects from SSRI antidepressants. http://en.wikipedia.org/wiki/Serotonin_syndrome 90% or so of your serotonin is in the peripheral areas of the body. GI tract and platelets mostly. |
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Since people are "coming out" here as bare footers, I'm wondering about something else...most folks here say that the cold weather is what bothers their feet the most. I'm just the opposite. One thing that really puts me over the edge is hot sun shining on my feet. Going to the beach is really tricky without ruining everyone else's fun. The key is my own big umbrella and a spray bottle. Also, white socks under these circustances can be better than bare feet under sandals/slides if I wet them down with cold water. I don't care if I look stupid.
Is anyone else here sensitive to the heat like this? |
I am very sensitive to the heat. Summer is when I get most of my burning attacks. That is when I hit the Biofreeze the most.
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A lot of people--
--especially those with a demyelinating component to their neuropathy, find heat more difficult to tolerate than cold, as heat is the enemy of "clean" nerve transmission, and if one had myelin damage the nerves are not transmitting that cleanly to begin with.
The MS people know this well--and there are many products on the market, such as cooling water vets, that are made primarily for them. And savvy neurologists know that nerve conduction studies are supposed to be done in a relatively cool room. |
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