Initially, when Tramadol was marketed, it was said to not have the potential for 'dependence'.

As far as using it, it if works, I see no problem. Very little of what they offer us doesn't cause some kind of dependence issue, or major side effects.

The only issue I see is the original poster is on 2 serotonergic drugs.

I'm on the 2 serotonergic drugs (Cymbalta and Pamelor) so that I can either drop back on the dosage of Neurontin or get off of the Cymbalta.

Tramadol is serotonergic as well.

Ultimately, I think a lot of us have tried a significant number of these medications, and really, none of them work totally. It's a personal journey to find what works 'somewhat' and doesn't cause you a lot of side effects. Some are luckier than others. The best I get to is feeling is, like I was run over by a truck....and the worst, wishing that truck had done me in.

Neuropathy is vast in scope and on a continuum. It is a component of hundreds of diseases, and also a disease on it's own. The only issue I see, is the potential for more drugs to interact....versus using one or two that don't. My personal opinion is that serotonin is a bit over-rated. If some is good, more is not always better. It's pretty much like that with all drugs.

It's not a judgment issue, it's no value attached. If serotonin works, great, if opiates work, fine. Like I said, I would eat raw yak liver, if it worked. I would hold my nose tho.

I think that raw Yak liver would smell like........... liver.
Most liver, smells just like .....liver.

There's excellent reason for that.

It's because it's.... liver.

that cmybalta is wild stuff be careful . and the tramado er doesn't work as well as the reg tramadol ... I take reg tramadol 100 mg 4 times a day

Hi Raz,

Any idea why that might be?

Doc

I agree! It does give some a big happy boost and that's is hard to not want all the time.

I have idiopathic pnp. I suspect it came about after I received a spinal while giving birth.The nurse had to jab me a couple of times to find the correct injection site.I have suffered from break through pain from over sensitive genital area touch. Please have any female members on this thread ever encountered this type of pain? Please don,t think I am pranking the thread; this is very real.Oh I was on tramadol and neurontin for a long while but my doctor took me off of the tramadol.I didnt have any bad experience with the tramadol, I believe my doctor was afraid I'd become addicted.

In my research i did come across some information pertaining to oxalates and vulva pain. I'm not well versed in this but you may want to check it out. And no i can't imagine anyone with idiopathic pnp pranking any thread.