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11-18-2011, 02:04 PM | #1 | ||
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I tried to find some information that would clarify some of the ideas here but didn't have much luck so the best I can say is that there does seem to be a trigger somehow between cortisol levels and the pain of PN.
I've been on a steroid inhaler for 7 years that can "rarely" cause adrenal suppression. My pulmonologist likes to 'mushroom' his patients (keep them in the dark and feed them BS) so I can't say for sure I have it, but I've developed weird allergies and apparent asthma, went into hypovolemic shock from the laxative when I had a colonoscopy (eek) and a few weeks later had what appeared to be a convulsion in response to extreme stomach pain. My COPD isn't severe enough to make me that fragile and from what I've read problems in tolerating physical stress are characteristic of adrenal suppression. My body temperature dropped a degree at some point after I started it as well. I didn't have any PN until I'd been on the meds for 2-3 years and there seems to be a pretty direct linear relationship between the amount of steroid I'm taking and the degree of pain, more drug = more pain. I tried to go off it entirely but couldn't breathe (it can 'worsen' asthma, I think it can GIVE you asthma). I stopped it a couple of times and the first time I restarted it I could feel a burst of burning/prickling in my feet shortly after I took it, and the second time I could actually feel it traveling down my thigh and hitting my feet to cause burning. I don't know if I was feeling nerve transmission or if the sensation was vascular but I felt it. It is known to cause muscle rigidity and stiffness that seems to target the small neck muscles and I also felt a little 'herky-jerky' sensation in my neck that felt like you might think a nerve transmission could and my neck stiffened back up. I don't know if that was nerves or muscles though. I'm not sure how much of this is relevant to people who may have natural suppression but cortisol levels vary throughout the day and maybe pain could occur when you get a burst and your nerves just don't appreciate too wide of fluctuations. I don't know what is going on with the heat, my feet get hot to the touch too but I thought that was vascular. It does feel like the nerves are revved up and generating heat more than the warmth you get from a hot bath or something. My pain is rarely if ever triggered by a bath, etc, it takes prolonged exposure like hot weather. I'm not sure if I exactly fit here, but I really admire the people in this forum. I know how much it hurts and you keep on truckin' and trying to learn. ' Zygo "Take 2 cats and call me in the morning".. |
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12-09-2011, 03:10 AM | #2 | ||
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I am now exploring endocrine disorders relating to PN. The US govt website says:
"Systemic diseases — disorders that affect the entire body — often cause peripheral neuropathy. These disorders may include: Metabolic and endocrine disorders. Nerve tissues are highly vulnerable to damage from diseases that impair the body's ability to transform nutrients into energy, process waste products, or manufacture the substances that make up living tissue." I've had chronic fatigue for a long time and suspect adrenal sufficiency. (I never have reserves for a crisis.) I don't know if you need a disease per se, as the article suggests, to get PN, or simply any kind of endocrine weakness that is systemic and/or chronic. I wonder how common PN is with those who have CFS. Since Magnesium and Taurine deficiency both impair the body's ability to transform nutrients into energy, presumably deficiency in one or especially both can lead to PN. Stress, which is a common known cause of PN, incidentally, depletes Mg. Lack of meat in your diet can deplete Taurine. I used to have a lot of stress and have not eaten much meat since 1999. |
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11-17-2011, 06:36 PM | #3 | |||
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Senior Member (**Dr Smith is named after a character from Lost in Space, not a medical doctor)
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Did it really say that? I must have missed that part. I haven't gone back to check, but my impression was that it was talking about nerves "burning up (or out)" figuratively. Sure, electrical impulses travel along nerves, but the amperages, voltages, and impedances/resistances involved are so low as to have little, if any, effect on body temperature. To produce heat electrically, a combination of high voltage/amperage and (especially) impedance/resistance are required.
http://en.wikipedia.org/wiki/Action_potential Body temperature (and changes therein) in endotherms (like humans) is accomplished by chemical reactions - the "burning" (oxidation) of fats & sugars. http://en.wikipedia.org/wiki/Endotherm Maybe I didn't sleep through most of high school biolog after all(?) Doc
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Dr. Zachary Smith Oh, the pain... THE PAIN... Dr. Smith is NOT a medical doctor. He was a character from LOST IN SPACE. All opinions expressed are my own. For medical advice/opinion, consult your doctor. |
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