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I don't do well with medications and have not been able to tolerate or function (have a life) with many of the traditional medications to help with the pain and symptoms of neuropathy. The neuropathy in the past year is progressing up the legs and now in hands and arms. My neurologist started me on a low dose of nortriptyline with an increase by 10mg every week till I reached 50mg per day. I have to admit it helped with the pain, burning etc. and added benefit was lost of appetite. Now the bad news at about the 40 mg level noted some shortness of breathe when only walking short distance. Spoke to Dr. and she wanted me to stick with it. I know she is frustrated that I give up on medications when I get weird feelings and brain fog. So this happened when we out in WA visiting family. Get back home and I check my BP and pulse and the BP is lower then normal (hx of high BP on 2 different meds for) and pulse in the 80's. Okay I am on a large does of beta blocker so my heart rate is between 55 to 65 even with exercise. I knew if I called my gp he would not see what the problem was so waited and 2 days later SOB up pulse now 90'sw and 100's. Call my neurologist so she knew what was happening and make appt. for next day to see GP. Well I got his attention, EKG show heart rate of 110 and a rt bundle branch block which means electric problem to heart and echo heart ultrasound was normal. He spoke to a cardiologist who saw me the same day and they both agree with me that it's the nortriptyline. During all this time I am trying not to passout. Well been off nortriptyline and it should be out of system but no improvement with heart rate. BP a little higher with only on beta blocker not other BP med. Now worried that this may be autonomic dysfunction. Anyone had problems like this. Of course pain is back also.