I finally took the tiger by the tail and had my genome tested commercially by one of the services that does AUTOSOMAL DNA testing. Additionally, there are FREE ADD ON programs that you can run your raw data thru to really look at things. I don't want to advertise, but if any one looks for gene testing companies, this one runs $149. Yes, that's all. They give you a great interactive web site. They list your mutations and what diseases they are associated with.

I highly, highly recommend doing this. I don't know what caused my PN yet, however, I found out I carry a lot of mutations for diseases that are associated with PN.

I also have a LOT of gene mutations associated with Celiac Disease. I have been tested several times, always by the same guy, but, after going gluten free for 3 weeks, I went in for an ANA and it was NEGATIVE! After 6 years of having a high ANA, whether on IVIG or not, it came back negative.....Hmm. I found out I am an FUT2 non-secretor which means my mucous and epithelial tissue does not secrete blood antigens when it attacks virus or foreign invaders. About 20% of the population carries this, and I wonder how this affects immune response in general. It confers norovirus resistance.

I feel ever so slightly better, but, I don't expect miracles.

Also, the test came back with MANY drug polymorphisms. I can't take many drugs given for this condition, nor the other common conditions we see. I am a a very high risk for myopathy from statins. I metabolize amitryptiline and SSRIs very slowly as well as some anti seizure meds. I metabolize all NSAIDS including aspirin very slowly. I don't do well with Wafarrin either. I slowly metabolize caffeine. I have several enzymes in my liver that don't metabolize drugs properly. There is additional raw data that will be of use in the future.

I may have some issues with a gene involved with CMT and HNPP.

Altho there is no 'ah ha' moment which will lead to diagnosis, there are significant medical and lifestyle decisions I am making based on knowing what my body is naturally all about!

I am waiting for results of medical testing to see if there is a mitochondrial issue via several nuclear genes that influence mitochondrial. The 24 nuclear panel. This is second line testing after your mito genes come back typical.

After poking thru the genome, I understand how primitive 'modern' medicine really is. Wow.