So far, the materials that i can tolerate is a combination of rayon and lycra. preferably, I'd get a material with more % of lycra than rayon. This, is during those days when my skin is "cooperative", otherwise, even the softest fleece would bother me. sometimes on good days, i also could wear jeans with no problem at all.

Thanks for the quick response.

* Yes the burning, sensitivity is primarily on the thighs (both). I do feel sharp tingles/stabs in my feet, toes, legs at times (random, short bursts) but the burning feeling of cloth touching the skin is painful only on the thighs. Even when the pant is touching the lower part of my leg (below knees) I feel no such burning there.
* I took Atenolol for many years (5+) and then switched to Lisinopril - I believe my primary care doc made this switch when he started to hear of my burning symptoms on my thigh. Apparently Atenolol is not as "safe" as Lisinopril. I had this thigh burning issue for about a year before I started Lisinopril.
* The neurologist did suggest meralgia paresthetica but that is typically on one leg and not both at the same time. But I am getting a prescription for lidocaine and I will try putting some near the sides (doc showed me where).

I found only one place worked for Lidoderm patches for me.
Right at the top of the thigh where the nerve exists the abdomen.
Also it takes several days to work up to the nerve in order to
suppress signals. It is not a quick fix.

MP comes from the back. It is also present in people wearing tight waist belts, etc, and also tight jeans. The nerve can be damaged while traveling thru the abdomen...which is how mine occurred.

I'd really suggest you get another drug, not in the ACE family for a while and see what happens. I am another person, since my ordeal. I was on those evil drugs (vasotec, accupril, and finally lisinopril) for 10 yrs! Until the bradykinin built up to overflow into other bodily systems... neither I nor my doctor suspected a thing.

I did not find lidocaine worked at the end points of pain in the thigh. Only at the location, shown on that diagram I gave you the link to.
Some people do get MP from lumbar compressions, but that is less common.

As an occupational therapist I've worked with many people, particularly on the autism spectrum, who have super sensitive skin. Fifteen percent of the normal population is suspected to have that condition to varying degrees, (and/or hypersensitivity to smell, light, movement, etc) which we call sensory defensiveness. Paradoxically, deep pressure touch can mediate the sensitivity to light touch, but I don't know if that would apply to PN pain. My patients with tactile hypersensitivity often were comfortable with close-fitting stretchy garments such as bike shorts or compression garments under their other clothing. When it's not too hot out, of course. Another strategy is to buy used clothes that are already broken in and softened and without buttons, zippers, etc.

Great inputs. I have certainly experienced that if I press down on top of my pants it feels better. I've spent a lot of time trying to find the ideal pant but maybe the focus should be on under garments. And I would have hoped there would be companies out there catering to this hypersensitive segment especially if it is 15% of the population. Several other posts describe different materials working for different people (all outer garments) - from cotton, to lycra, water proof sportswear, micro-fiber, etc. I too went through an exercise of trying out 10's of pants and capturing inputs into a spreadsheet. Probably 50 at end count of all types. Sadly almost all got checked off and then its become a matter of settling for the best of the worst - 100% cotton pants as soft as I can find them (and they are very hard if not impossible to find). If someone out there wants to see it I can make my pants research available. But I will now move into under garments research! Silk boxers, Mens' spanx, etc. Strange places this PN takes us.