I thought I would start by taking one then build up to the 2nd one , as I don't need that to hit while i'm teaching on Monday and Tues so then by Wednesday if no reaction I'll go to two a day. I just got the prescription yesterday , leaving in a bit to run errands so will start at dinner . Husband was on Metformin for about 6 months ( did excellent now just diet and exercise and has been 5 years ) he didn't have any upset , if anyone would he would lol. So I hope not to but if I do I'll have to work around it I guess for a brief time but it will be worth it to get things on the right track .