Asians do have problems with genetics.... they have reduced
liver enzymes for some drugs...like Crestor.
Also alcohol is difficult for many Asians.

http://www.healthanddna.com/healthca...enotyping.html

http://medicine.iupui.edu/clinpharm/ddis/table.aspx
The 2C9 pathway may be impaired in some Asian patients.
Notice the NSAIDs which you cannot tolerate are there in that list.

I wish I had known this before, that you are Asian. How your genetic makeup handles drugs may be a key to some of your problems.

ideopathic pn i dont know anything about symbicort and its relation to pn and nerves in general.

i dont feel that the medicines that i have been taking for asthma have contributed much to the progression of my pn. i actually developed pn at the same time as i first started coughing and wheezing and developing numerous respiratory infections. so that pre dates the medicine for asthma. ive been hospitalized for asthma a number of times for a week or more. ive had episodes of not being able to take more than a half breath without a coughing fit for over 12 weeks. so if i didnt take care of my asthma aggressively years ago im sure i would be dead.

i know how you feel with the multiple problems and feeling overwhelmed at times.

My mistake, I knew about the connection between Asian ethnicity and 2C9 but I was just looking at the 3A4 for the steroid. According to what I see the formoterol goes through 2D6, 2C19, 2C9. and 2A6. I don't know if that means it can be metabolized by any of them or if its sequential, the product of the first is acted on by the second, etc.

judi

SE= side effects

Oh, thank you!!!

Mrs.D, this is too complicated to comprehend for me

I will re-read the whole thing ..... thank you