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Old 05-14-2012, 05:04 AM #21
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Originally Posted by Sallysblooms View Post
I cannot see the link.
When you go to that link, you have to put in the search box in the upper left, "fluoroquinolones" . The first article that comes up is the one listing the drugs. That site has a strict copyright rule so we cannot copy that information here.

Some websites do not give individual addresses to their sub categories. This is one of those. The FDA.gov is another.
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Last edited by mrsD; 05-14-2012 at 02:27 PM. Reason: fixing spelling
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Old 05-14-2012, 07:27 AM #22
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I was diagnosed with Ileocecal TB in 2000 or 2001. I was on treatment supposedly for 6 months but because of nausea and vomitting, my dosage was adjusted up and down depending on my tolerance. So, the whole course was extended to 9 months.

I forgot the name of the antibiotic I was on.

Assuming the TB medication is the cause of my PN, does it take 10 years to show the symptoms of the damage?
It would depend on what you took. Some of the drugs are harsher than others.
http://en.wikipedia.org/wiki/Rifampicin
This drug is often combined with isoniazid.
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Old 05-14-2012, 02:21 PM #23
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Originally Posted by mrsD View Post
It would depend on what you took. Some of the drugs are harsher than others.
http://en.wikipedia.org/wiki/Rifampicin
This drug is often combined with isoniazid.
Oh my, I think thisis the medicine I took. I just dont remember if I took it along with isoniazid.

In that case Mrs.D, does it take this long to show its effects on my nerves?

What are the supplements that directly address the damage of antibiotics? Is it R-Lipoic, Acetyl L-Carnitine and CoQ10? I hope that if it was the TB medication, I hope I can still reverse some damage. I really hope so.....

Thank you.
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Old 05-14-2012, 02:32 PM #24
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What may happen is that the damage was done then, but the body can compensate for a while, until another thing comes along to do some damage. It might take a few hits to accumulate damage.
It used to be thought that PN was an old person's disease, meaning it came with age. Some doctors still treat it this way. Age means decline, so some internal decline may be there --mitochondrial aging-- which when mixed with early damage, may result in earlier symptoms. It is just really a complex thing PN.. There is no one answer for everyone.

PN appears to be an environmental type problem for many.

Some of us have metabolic triggers, but for others it is toxins, drugs, solvents, viruses, bacteria, vaccines, certain foods, etc. Things we come in contact with.

The supplements for mitochondrial support are:
Lipoic acid
acetyl carnitine
CoQ-10
Some mito supplements have biotin in them, too.

Here is one site with suggestions:
http://www.lef.org/magazine/mag2010/...-Damage_01.htm
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Old 05-14-2012, 07:20 PM #25
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Originally Posted by mrsD View Post
What may happen is that the damage was done then, but the body can compensate for a while, until another thing comes along to do some damage. It might take a few hits to accumulate damage.
It used to be thought that PN was an old person's disease, meaning it came with age. Some doctors still treat it this way. Age means decline, so some internal decline may be there --mitochondrial aging-- which when mixed with early damage, may result in earlier symptoms. It is just really a complex thing PN.. There is no one answer for everyone.

PN appears to be an environmental type problem for many.

Some of us have metabolic triggers, but for others it is toxins, drugs, solvents, viruses, bacteria, vaccines, certain foods, etc. Things we come in contact with.

The supplements for mitochondrial support are:
Lipoic acid
acetyl carnitine
CoQ-10
Some mito supplements have biotin in them, too.

Here is one site with suggestions:
http://www.lef.org/magazine/mag2010/...-Damage_01.htm
Dear Mrs.D,

I am currently taking all 3 supplements for mito support. I wonder if I need to take R-Lipoic (100mg) and CoQ10 (100mg) 2x a day instead of 1x. Due to my shortness of breath issue, I take the CoQ10, R-Lipoic and SAM-e one after the other. But with this new information about TB medication, I am considering of doubling the dosage for the mito support. What do you think Mrs.D?

It says in your link that molecular decay and membrane injury begin to appear and can be detected nearly a decade before the onset of permanent damage to the DNA. Well, I want to interprete this in my favor to mean that my nerves can still be saved. I hope so....

From the time I had the whole course of TB treatment, the only medicines I remember taking on a regular "as needed basis" are meclizine, glucosamine, occasional Bactrim, 2- short courses of Prednisone, and the the only new thing I did for the past 3 consecutive years is the flu vaccine. At this point, there is no way of knowing if it was indeed the TB and flu vaccine that caused my PN. But, for my peace of mind, I still want to ask this question : Is there a test to confirm the suspicion on antibiotic induced PN?

Thank you Mrs.D.
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Old 05-14-2012, 11:41 PM #26
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What type of CoQ-10 did you get? Is it the new one--water soluble type? You need less of the water soluble type since it is better absorbed.

Are you taking Acetyl Carnitine too?

I'd keep the lipoic at 100mg a day, but you can increase the CoQ-10 if you decide to. CoQ-10 is a slow onset supplement. So give it time to work.

There is not test I am aware of yet, for drug induced damage to mitochondria.

There is a test for people with genetic mitochondrial issues.
But it is not commonly done for other reasons.
http://www.mitoaction.org/testing-fo...ease-disorders
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Old 05-15-2012, 02:41 PM #27
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What type of CoQ-10 did you get? Is it the new one--water soluble type? You need less of the water soluble type since it is better absorbed.

Are you taking Acetyl Carnitine too?

I'd keep the lipoic at 100mg a day, but you can increase the CoQ-10 if you decide to. CoQ-10 is a slow onset supplement. So give it time to work.

There is not test I am aware of yet, for drug induced damage to mitochondria.

There is a test for people with genetic mitochondrial issues.
But it is not commonly done for other reasons.
http://www.mitoaction.org/testing-fo...ease-disorders
My CoQ10 is 100mg- a soft gel in form. I bought it at Sams. I think this is the old version. I started it early March. I should now start taking the COQ10 together with the other supplements which I take 2x a day:

Acetyl L Carnitine 250mg
Benfotiamine 150mg
Omega 3,6,9

Okay, I will take the R Lipoic just once a day at 100mg.


Yes, I am taking the Acetyl L-Carnitine 2X a day at 250mg each. I am also taking Benfotiamine 2x a day at 150mg each.


Thank you so much.
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Old 05-15-2012, 03:59 PM #28
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That older version of CoQ-10.... if it lists oils as the carrier, you can take up to 300mg a day.

The water soluble ones, say so, and they need less, like 100mg a day.

Repairing mito functions or damage in general takes time. It is not a speedy result. 2-3 months average.
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Old 05-15-2012, 04:39 PM #29
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Going back to the antibiotics, is there ANY of them to have in case I need them in the future? I know they each treat difference bacteria of course. I am at a loss. I would love to have a little list of less toxic ones.
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Old 05-15-2012, 05:06 PM #30
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i use biaxin and zithromax for respiratory infection, without any apparant ill effects.
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