Interesting side effect observation on your part. Not only do I have an MTHFR mutation, I do have EDS. I've had subluxation/dislocation problems all my life. The rabies vaccine did not seem to make the subluxations any worse for me, but I am older (now 68 years old) and the subluxations have become less of a problem as my tendons and ligaments stiffen with age. For those of us with MTHFR, EDS, and mast cell activation syndrome, pharmaceuticals and toxins can play havoc with any and all of our organs and tissues. One of the things I did to heal that did a great deal of good was to make home made bone broth and drinking a cup daily. Be sure to use only ORGANIC FREE RANGE animal bones when making the broth.