newbie & newly diagnosed with PN in my feet

bananababe · 09-13-2012, 01:03 PM

Quote:

Originally Posted by mrsD

I believe Stacy is meaning the "old" lab ranges showing low numbers as normal.

Also if you have inactive B12 in your serum from supplements, and you have the MTHFR genetic mutation that prevents conversion to active methyl form, you would test higher, and still the B12 would not be working. An MMA test will reveal if your B12 is working for you. Or you could get the DNA test for the MTHFR polymorphisms.

If you are taking B12 already, it will read high in testing serum.

Thank you, this is very helpful! Can you please tell me what an MMA test is?

Also, I didn't mean to highjack this thread. Should I have created a new one?

mrsD · 09-13-2012, 01:51 PM

MMA:

http://labtestsonline.org/understand...s/mma/tab/test

If this test is LOW that means your B12 in your blood serum is working. If it is high, then B12 is not.

You can also do a homocysteine test, and if high it indicates that something in the conversion of homocysteine to SAM is not working. 3 vitamins are involved in this conversion,
methylB12
methylfolate
pyridoxal 5 phosphate (which is activated B6 pyridoxine)

Usually the MMA test is enough to confirm a confusing B12 serum result.

Stacy2012 · 09-13-2012, 04:31 PM

My MMA and Serum tests were skewed because as MrsD said, I did not stop taking B supplements before the test, as at that time I did not know I should, and therefore the serum was useless to me. The MMA came in at the low end of normal.

I did not bother with any further testing, as I just started on 5,000 (mcg or mg? one of them) of the B12 and since it is helping me, I continue to take it and B12 toxicity is rare.

bananababe · 09-14-2012, 12:45 PM

Thank you for all the helpful information.

Do you know how long you'd need to stop taking B supplements before testing?

Stacy2012 · 09-14-2012, 01:27 PM

I think I remember reading a couple days. However, I personally would stop taking them at least a week to make sure since I am on such high doses.

bananababe · 09-16-2012, 03:48 PM

Thank you!

bernadettemarie · 09-16-2012, 08:42 PM

going to rhemotologist? I've been suffering for quite awhile with burning, tingling etc. Started suddenly at gym years ago. Always had back issues, so I assumed I was workinging out to much and took some time off. Didnt get better. Went to primary doc...rhemo panel came back as autoimmune problem. Going through bad flare now and really can't get accurate diagnoses. Meds have been helping with symptoms, but feet and hands getting spots of numb and unable to feel hot/cold. Good luck

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