Has anyone ever read or heard of anything that would link niaspan to peripeheral neuropathy, or in my case small fiber neuropathy? I think I had my first neuropathy symptom ever a few months after starting Niaspan, but based on my conversations with my doctors along with some internet research I have not really seen anything to link it with neuropathy, unlike the statins, which there has pretty clearly been an established link.

I'm on Niaspan because of an EXTREMELY high lipoprotein(a) reading, which is a cardiovascular risk factor. The Niaspan has brought it down quite a bit.

Niaspan can cause tingling/burning...part of the "flush".

You can test this by taking aspirin about 45 minutes before the Niaspan.

Over time niacin can raise blood sugar..when this happens, PN can happen.

High dose Niacin also can affect the liver. If you have liver damage you could get PN type symptoms.

High dose niacin is not innocuous... it can have toxicity.

You can test this by stopping the Niaspan.... wait 2 months or so and
see if anything changes.

I am on Niaspan for high cholesterol. I take 2000 mg per day. I thought there could be connection to PN as symptoms started right afterward. I stopped drug and they did not improve. I am now back on it. My insurance won't cover the Rx Niaspan so now I need to go out and buy the over the counter niacin.