I do notice my symptoms cycle every few weeks. They get really bad, then wind down then speed up again. Is this typical?

I am getting worried because the neuropathies seem to be getting worse instead of better.

I was healing (2 weeks of no neuropathy) and then went to the chiopracter may 1 and the neuropathies came back 100x worse than before and also started up atonomic dysfunction. It has not gone away since and a painful part of every day. I can't help but think the chiopracter released toxins from my joints effecting the CNS. Is this possible?

Also:

Originally this was from a flagyl reaction, but I was under extreme stress at the time. I was fighting an unknown virus (stress on body) and also thought I had contracted HIV and given it to my newborn daughter (extreme emotional stress.) I found in the book "bitter pills" that this may have increased the severity of CNS reaction.

Talking about solders sick after being made to take strong antibiotics to fight chemical warfare:

A certain percent will have reacted to these drugs, especially while under the stress of a combat situation and the likelihood of head traumas, which is a cofactor in developing a severe CNS reaction to FQs (see "Bitter Pills" by Stephen Fried, pg 38-39).

Apologies if I ask for the obvious, and you probably already thought of that, but are they following your menstrual cycle?

I just happened to see a documentary on women who had horrible hormone swings that went way beyond "just being a bit grumpy". Food seemed to play a big part, and they normally found out after an elimination diet. Your condition might get worse in the same way (I'm not saying they are causing it).

That said, your symptoms sound worrying to me, and I hope you have someone around who can keep an eye/call a doc when things go bad. I'm not a doctor, but problems with your heartbeat and other symptoms make me think about toxins before they make me think of "just" autonomic PN.

Other question: are you hyperventilating?

Flagyl is not a fluoroquinolone.

It is chemically different, and will not necessarily cause the damage the same way the fluoroquinolones do.
http://en.wikipedia.org/wiki/Metronidazole

I'm not menstrating as I had a baby on NYE and was breastfeeding. So it hasn't come back yet.

And no I'm not hyperventilating. This is not the cause of the PN. It hits me all day everyday. It is always on feet (worst part), hands, arms, and constantly moves around rest of body or all of body.

This is not a migraine. It's been neurologist confirmed PN and autonomic.

I think that in order to get a handle on these symptoms you will need to keep a journal...log your blood pressure in the morning and evening at least. It will tend to be a bit higher in the morning or after a large meal. If you can, even take your temperature, to see if the attacks have a cyclic fever involved. Many autoimmune problems come with cycling fevers.

Also journal what you eat each day, and your symptoms each day.
If there is a trigger that causes this cycling you will find it.
Sometimes the foods give the reactions hours or a day after you have consumed them.

Allergists really love journal keeping...as they can then see trends.

I think it is always helpful for doctors to see stats/vitals logged as this is what they look at when you are in the hospital.

Thanks. I've been all over that wiki site as well as every other publication I can get my hands on regarding metronidazole.

I'm aware its not an FQ, but its just that my reactions are so severe (and unique!) and I can't help but think that there are some strong similarities to the way my neuropathies developed as I was under extreme physical and mental stress at time if onset. And both FQs and Metrodonzadole are both so toxic to the CNS.

Now I'm getting worried this could be ischemic.

I'm sorry to be questioning this so much, but I'm in an extreme amount if pain and bed ridden. I had 1 hour sleep last night and can barely walk. I'm hanging on by a thread. I was a healthy active and fit mother three months ago. Now I can't even attempt a flight of stairs.

My symptoms are ALWAYS worse right before I start my period. I have watched the cycle every month, and no doubt the hormones must play a role in my pn.

All antibiotics work slightly differently... some work on DNA, some on cell walls, some in mitochondria of the target organism etc.

The key here is that metronidazole targets predominately ANAEROBIC cells... cells that do not get much oxygen. Therefore it is used for specific infections caused by anaerobic bacteria.
It does not affect the host cells in the same way. Bone/tooth, intestinal and vaginal infections are typically what it is used for in humans.

Fluoroquinolones are different and they disrupt DNA strands, and this is the key to their specific toxicity. They are used for all sorts of infections and have a wider range on different organisms.

Your problems may involve that virus you had, because viruses will attack the dorsal root ganglia along the spine. The herpes zoster virus (shingles) for example, does this. Dorsal root damage can appear "all over" as you describe.
Viruses can attack the brain and spinal cord too. It would depend on the person and their own immune system potential.

You may be onto something. I'm much worse when I am immune compromised, like when I have a cold. When viruses become dormant, do nerves heal?