I was just told that I should try adenosyl B12, sold as Dibencozide for my pn along with the methyl B12. She said sometimes if methyl is not working this other one helps more.

Guess I will go on another search to see if anything comes up with this, thought I would start here.

This is discussed in detail on the B12 thread.

Since all the details about why we have more than one activated form in the body, are not elucidated yet... it can't hurt to try the other. It is less commonly found, and may cost more than methyl, but it is OTC and available. I think it preceded methyl OTC as I used to use it over a decade ago... Country Life brand.

But as methyl became so inexpensive and was taken up by so many manufacturers, I switched to methyl myself.

Ya, she said I may be having problems absorbing the methyl. It would make sense because I have never felt any difference taking my B12, I take it because I should but never "felt" anything, not that we always feel something when taking a supplement.

Anyone here use this form or has used this form of B12?

It is not a matter of "absorption"... it is a matter of where in the body the various active forms of B12 actually work. That is a totally different thing and still only theorized.

I always use Methyl B12.

In trying to understand more I found this:

Taking B12 orally will allow the body to absorb only a small amount, a few micrograms. If you inject it or take it sublingually, much larger dosages can be put into the blood. In treating ME/CFS, we have found that the dosage needs to be fairly high, usually of the order of a milligram (1000 micrograms) or more.

The concept of being a "slow methylator" comes from Dr. Amy Yasko. She finds that if a person has inherited certain genetic variations (SNPs) in the genes that code for the COMT (catechol-O-methyltransferase) enzyme and the VDR (vitamin D receptor), then their body will not be able to utilized methyl groups at as high a rate as normal. According to her, if such a person takes supplements containing methyl groups, they can experience symptoms such as you have described. I don't think this has been independently confirmed by other researchers, but Dr. Yasko has been giving this guidance for several years now. It is included in her book "Autism, Pathways to Recovery," and she advises many people (mostly mothers of autistic children) about this in her internet forum at www.ch3nutrigenomics.com which now has over 12,000 members. She advises people who are slow methylators to take hydroxocobalamin rather than methylcobalamin, and to minimize other supplements that have methyl groups.

You may have built up excess methyl groups over time. Perhaps lower dosages, skipping days, or shifting to hydroxocobalamin would help.