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Old 03-24-2014, 10:04 AM #11
Stacy2012 Stacy2012 is offline
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I guess I am missing it, I don't understand.

I did go read your links.

I will try and google more.
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Old 03-24-2014, 10:18 AM #12
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From the Wiki article:

Quote:
Pharmacological doses of niacin (1.5 - 6 g per day) lead to side effects that can include dermatological conditions such as skin flushing and itching, dry skin, and skin rashes including eczema exacerbation and acanthosis nigricans. Some of these symptoms are generally related to niacin's role as the rate limiting cofactor in the histidine decarboxylase enzyme which converts l-histidine into histamine.[citation needed] H1 and H2 receptor mediated histamine is metabolized via a sequence of mono (or di-) amine oxidase and COMT into methylhistamine which is then conjugated through the liver's CYP450 pathways. Persistent flushing and other symptoms may indicate deficiencies in one or more of the cofactors responsible for this enzymatic cascade. Gastrointestinal complaints, such as dyspepsia (indigestion), nausea and liver toxicity fulminant hepatic failure, have also been reported. Side effects of hyperglycemia, cardiac arrhythmias and "birth defects in experimental animals" have also been reported.[62]
This quote is for NIACIN and not inositol hexanicotinate (non-flush variety).

So does your label say NIACIN? Can you give me a link to your
product online?
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Old 03-24-2014, 10:30 AM #13
Stacy2012 Stacy2012 is offline
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This is the product:

http://www.optimox.com/pics/ATP_Cofact.htm

Same as you had posted earlier. I got it on amazon:

http://www.amazon.com/OPTIMOX-ATP-Co.../dp/B002D9DFQ2


A specially formulated high potency vitamins B-2/B-3 combination, containing100mg of Riboflavin and 500mg of Niacin (as Inositol hexanicotinate) per tablet

So, I am not sure what this means, I guess I am slow. I mean it is as you say, the non flush kind. And it did not cause normal flush or any other symptom but it is the cause of my pain
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Old 03-24-2014, 11:15 AM #14
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Thanks for the link... that is the one I found too.


What this means is that you did not get real flushing Niacin in that tablet. It has the non-flush form inositol hexanicotinate.
from your link:
Quote:
IV. SIDE EFFECTS

The flushing associated with niacin is avoided by using a non flushing derivative of niacin. The Urine turns dark yellow due to the excretion of Riboflavin and may stain undergarment in subjects with urinary incontinence.
This only makes a difference because the NON flush type does not act on cholesterol lowering.

It is not really typical to find OTC very high dose NIACIN...that flushes. There are some delayed release types OTC but they are less common.

High dose niacin requires periodic monitoring of liver functions, so is not used OTC much at all. The RX versions are 500mg - 1000mg

It is conceivably possible to flush with the non flush type, but very very rare. (just because 100% never exists in biological systems)

I'll try to search this histadine metabolic error later this week sometime for you.
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Old 03-24-2014, 12:44 PM #15
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Ya I read that too which is why I don't understand why it hurt my feet so bad. And it only hurt my feet, nothing else.

Thanks MrsD!
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Old 03-24-2014, 02:10 PM #16
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It might be the serotonin thing... niacin is a precursor to serotonin.

Dr. Cohen has that too you know and he uses an antihistamine from Canada that blocks serotonin too. (like cyproheptadine here, which you could ask for as a trial).
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