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01-14-2015, 08:06 AM | #1 | ||
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Member
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GANGLIOSIDE(asialo-GM1)IGG/IGM came up positive for me. I get my blood tests through emails. The doctor hasn't called me yet. I am scared and wondering what this means for my future. Anyone know?
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01-14-2015, 10:23 AM | #2 | ||
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Junior Member
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I think it points to having an autoimmune cause to your neuropathy (antibodies specifically for peripheral nerves).
I wasn't tested for these, because my nerve conduction test and EMG were normal. It may open up treatment options for you, such as IVIG. |
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"Thanks for this!" says: | Healthgirl (01-14-2015) |
01-14-2015, 11:44 AM | #3 | ||
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Member
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I was also normal for the emg, but because of my symptoms he checked me for this. I am terrified because I think this is the antibody that commonly shows up for ALS.
I think we go to the same doc. I pm'd you. |
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01-14-2015, 11:57 AM | #4 | |||
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Wisest Elder Ever
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This PDF explains:
http://www.focusdx.com/focus/techshe...stingatMRL.pdf Several things may be happening....so your doctor will explain it to you in more detail.
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01-14-2015, 12:33 PM | #5 | ||
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Junior Member
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Yeah but ALS I hear is often a lack of sensation and feeling-as in there isn't really much physical pain involved. This antibody is common in several diagnoses, and ALS is exceedingly rare as a disease.
Was your nerve conduction test normal? |
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"Thanks for this!" says: | Healthgirl (01-14-2015) |
01-14-2015, 02:01 PM | #6 | ||
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Member
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I think in terms of ALS/MS these are more diagnostic if they are present in CSF. Have you had a spinal tap?
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Idiopathic Sensorimotor Polyneuropathy Atypical Migraine Chiari 1 malformation 7 mm PLIF L5-S1 Sept. 2013 Lumbar MRI March 2013: degenerative changes from L3 to S1. L3 and L4 have tiny annular tears with disc bulge. L5-S1 bilateral pars defects anterolisthesis (spondylosis/spondylithesis?) I have an annular tear here too, along with a conjoined left L5-S1 nerve root. Mild effacement of the thecal sac at the origins of the bilateral S1 nerve roots, left greater than right. Mild bilateral Neural foraminal stenosis. |
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"Thanks for this!" says: | Healthgirl (01-14-2015) |
01-14-2015, 04:27 PM | #7 | |||
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Magnate
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Guillain Barre is linked to ganglioside, but, in general, it is linked to autoimmune issues as well as a host of viral and bacterial diseases. Maybe he should re-run it and follow up on it to see if it is still a factor. It's amazing how little docs follow up on sometimes. I get sick of paying them when I do the work. :/
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"Thanks for this!" says: | Healthgirl (01-14-2015) |
01-14-2015, 04:31 PM | #8 | |||
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Magnate
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I have often told my doc and other people that my disease feels a lot like MS, and it just does. This is a very nasty neuropathy. My legs are often numb to the hips and when I stand it takes 5 minutes for me to regain feeling. Sometimes it is the hands and arms. Sometimes my face feels numb or tight. Sometimes it feels like my hair is being pulled. I could fill a page, but that won't help you. Call his secretary and ask for follow up. You are entitled to that.
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"Thanks for this!" says: | Healthgirl (01-15-2015) |
01-15-2015, 07:16 AM | #9 | ||
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Magnate
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--you can take a look at this (very comprehensive list of antibodies associated with structures of nerve and the associated conditions):
http://neuromuscular.wustl.edu/over/labdis.html#gm1 |
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"Thanks for this!" says: | cyclelops (01-16-2015), Healthgirl (01-15-2015) |
10-20-2015, 01:44 PM | #10 | ||
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Junior Member
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Hi there- I am going to a neuro on Monday to get tested for things that might run with a polyclonal IgM and nerve symptoms. i had a bout in 1999, it last six months, went away for 15 yrs and resurfaced in 2013.
a) can the antibodies react like that in a relapse and remit fashion; b) could they cause the polyclonal Igm themselves OR is there always something else that we don't know about (i.e, a cancer, infection, autoimmune). c) Also, can this antibody cause CNS issues as well - by that I mean mainly anxiety, racing feelings. Sometimes I think I have some of the paraneoplastic ones b/c those seem to run more with the psychosis, dementia, which is honestly what I feel like CRAZY amounts of anxiety. I ask b/c Ive been chasing down the source of this igM for 15 years and have gotten ZILCH. |
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