Hello

My pain in excruciating. It's literally everywhere . Most horrific burning and stinging ever. Plus just pain that travels on lines from back to scalp, arms and legs. Started nortryptiline 3 days ago and having zero relif. Pain worse than ever. I can't do anything but resting is worse. What med should I try next. I need something fast... I can't handle this. Really and truly I will not be able to handle this much linger.

Also, how would u know if ur sensory nerves were severed ? Or maybe not severed but almost severed?

Neurontin is a good option. But it takes a little time. You have to start at a low dose, and work your way up over many days and weeks. But it has a good success rate for these types of symptoms.

Have you tried the OTC Biofreeze for the burning?

The skin biopsy would detect whether the small fibers have been damaged. Part of the test is to examine the condition of the fibers...including segmented fibers and those with swellings or other signs of damage.

Tricyclics can take a month to 6 weeks to work. They are very
slow.

The doc and pharmacist said that for nerve pain it should give me relief in a couple days but that of depression it takes weeks. Is this true or have people found that it does take some time even for nerve damage . Also, what seems to be the effective dosage for nerve damage pain relief ? I've seen people say 10mg but it's doing nihing and neuro said keep going up till I got to 40. I haven't heard of people taking this much before except for depression where I know it goes higher

Many people here have reported getting great relief with cannabis.

There are lots of articles to read:

https://www.google.com/search?q=cann...m=122&ie=UTF-8


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I take 50mg daily and have a friend who takes 60mg. My neurologist says he's got people taking 150mg daily, for pain, which is at an antidepressant level. I found the benefit for me reached maximum at 2 months, but you should find some in a few days. At any rate, it sounds like you'll likely need more than 10mg.

I'm in the process of going off of Lyrica and going back to Nuerotin (Gralise). I really never gave Lyrica credit for what it does for pain relief, I can really feel it now.

What I know is you really don't feel the relief these drugs provide until you miss a dose or change.

The way tricyclics work is in the brain, where they tweak serotonin receptors to ignore pain signals.

So the sedation does come right away, but the real actions take weeks to manifest. The drug has to get to the centers necessary and thru the blood brain barrier, both situations that take time.

Nortriptyline and amitriptyline both show potential for peripheral nerve improvement by affecting nerve growth factors. This is also a slow process.

How could they affect nerve growth factors? Do you mean for nerve damage that occurred already vs ongoing attack from autoimmune cause?

Yes, I'll find the paper (again).... it has been posted here many times.

It is relatively new information.

http://psychcentral.com/news/2009/06...tors/6761.html

Nortriptyline is the active metabolite of amitriptyline.