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EnglishDave 06-01-2015 07:09 AM

For those who, like MrsD says, don't follow links:

Here is what I believe to be a relevant quote from the article that appears in the Wall Street Journal here:

http://www.wsj.com/articles/diabetes...ind-1432583222

==
Quote:

Alzheimer’s disease is still poorly understood and there are multiple risk factors that contribute to dementia, including genetics and age. Most people with diabetes won’t go on to develop Alzheimer’s disease and are able to live healthy, fully functional lives.

“If we prematurely equate diabetes with a condition as severe as dementia or Alzheimer’s, we’d be doing a great disservice to the 29 million people in this country who hold complex positions and fulfill complex job requirements,” says Samuel Dagogo-Jack, a diabetes specialist and professor of medicine at the University of Tennessee Health Science Center.
I am worried enough with the genetic predisposition and early onset lesions/ memory and cognitive issues (although I attribute some of this to meds) to have speculative links of my Diabetic condition being another trigger.

Dave.

EnglishDave 06-01-2015 09:51 AM

To clarify the earlier statement, quoted below, that I made in an earlier Post:

==
Quote:

While there MAY be links between uncontrolled blood sugar and ameloid formation, anyone who thinks that Diabetes and Alzheimer's are of the same Family have never had a Loved One stricken with any type of Dementia - had their life and self stripped away from them, had the family shattered by this cruellest of conditions.
I was referring to Researchers who are prone to making offhand 'Professional' statements with the bare minimum of data or facts, and who have no personal experience of either condition. I did not mean to negate the beliefs of fellow Members who HAVE the experiences these Researchers lack.

Dave.

janieg 06-01-2015 10:39 AM

I look at it a completely different way. If they can conclusively substantiate a link between AD and blood glucose issues, that brings diet into play as a means of trying to prevent development of the horrid disease. It puts some additional control into our hands because if there's ONE thing we can control, it's what we put in our mouths. That scenario is infinitely better than sitting back and hoping genetics doesn't just play out.

So stay mentally and physically active and now eat right to reduce your risk? It sounds pretty much like the ticket to stave off a lot of problems.

The appropriately named MIND diet is the one in the news, but it seems to have some components to it that would conflict with glucose management for someone with IGT.

New 'MIND' diet linked to reduced risk of Alzheimer's

http://www.medicalnewstoday.com/articles/291073.php

http://www.ncbi.nlm.nih.gov/pubmed/25681666

10 foods to eat per the MIND diet, 5 foods to avoid, nicely summarized at the end of this article:

http://www.express.co.uk/life-style/...-risk-dementia

______________________________

madisongrrl 06-01-2015 11:28 AM

And it's also good to remember that we aren't our genetics (except those that have something like Huntington's disease or are at risk for Huntington's disease - it is gene defect). Diseases are often complicated and multi-factorial; diseases express when our genetics and environment interact. So we just have to do our best to take charge of our environment by living the healthiest lifestyle we can. :)

EnglishDave 06-01-2015 11:32 AM

Again, another diet where elements contradict recommendations from other areas of expertese… and I note with some dismay that this study average only ran for 4.5 years - not a long time in the course of Alzheimer's decay. Even my Mum's most devastating type took 8 years to run it's inevitable course, and cognitive decline may have been hidden from us for longer.

Personally, I am much more excited by the link at the bottom of the article which leads here:

http://www.medicalnewstoday.com/articles/290801.php

A potential ultrasound treatment for those already suffering from plaque build-up.

Dave.

EnglishDave 06-01-2015 11:56 AM

Quote:

Originally Posted by madisongrrl (Post 1145666)
And it's also good to remember that we aren't our genetics (except those that have something like Huntington's disease or are at risk for Huntington's disease - it is gene defect). Diseases are often complicated and multi-factorial; diseases express when our genetics and environment interact. So we just have to do our best to take charge of our environment by living the healthiest lifestyle we can. :)

madisongrrl,

I agree, especially with Alzheimer's as it is the topic, that there are multiple factors. Personally, I believe that humans simply were not originally 'made' to live as long as modern nutrition and medicine allow. We simply wear out.

My dear Mum had a Country upbringing, the best fresh, organic (before the craze) home-grown foods, and adult life was healthy, apart from breast cancer. Her Mother had Dementia at the end of a similar life. My sister is showing brain shrinkage at age 60. That, at least shows a predisposition over 3 generations aside of outside influence - but that is just my family, and my personal experiences.

However, maybe my Mum and Grandmother both made it to around 70 before severe symptoms simply because they ate so healthily?! I inherited my Dad's heart and genetic predisposition to colorectal cancer - chances are I won't get that far:D

Dave

janieg 06-01-2015 12:19 PM

Quote:

Originally Posted by madisongrrl (Post 1145666)
And it's also good to remember that we aren't our genetics (except those that have something like Huntington's disease or are at risk for Huntington's disease - it is gene defect). Diseases are often complicated and multi-factorial; diseases express when our genetics and environment interact. So we just have to do our best to take charge of our environment by living the healthiest lifestyle we can. :)

Yes, I wholeheartedly believe this, especially in the case of Alzheimer's. I'm fortunate to not have inherited the APOE4 variant from my mom which increases risk, but I'm not "resting on my laurels" of that genetic good fortune as it's just one of many involved genes.

And lifestyle of course plays a huge role too. I'm infinitely more active both physically and mentally than Mom was, and intend to keep it that way. With preliminary research showing possible ties between AD and glucose issues, it's all the more reason to carefully watch my diet and have good glucose management which is what I've been doing anyway.

madisongrrl 06-01-2015 08:06 PM

Quote:

Originally Posted by janieg (Post 1145675)
Yes, I wholeheartedly believe this, especially in the case of Alzheimer's. I'm fortunate to not have inherited the APOE4 variant from my mom which increases risk, but I'm not "resting on my laurels" of that genetic good fortune as it's just one of many involved genes.

And lifestyle of course plays a huge role too. I'm infinitely more active both physically and mentally than Mom was, and intend to keep it that way. With preliminary research showing possible ties between AD and glucose issues, it's all the more reason to carefully watch my diet and have good glucose management which is what I've been doing anyway.

Totally agree! We need to stack the deck in our favor.

I don't have known diabetes or any glucose issues, but I did buy a glucose meter and am going to do some of my own investigations. Leave no stone unturned...

EnglishDave 06-02-2015 07:31 AM

Here is an interesting World Health Map (standardised) for rates of Alzheimer's/Dementia:

http://www.worldlifeexpectancy.com/c...ia/by-country/

There is a feature for selecting many causes of death Worldwide.

I note one very interesting area in particular. The English are a Germanic Race genetically, in the main, yet look at the incidence difference between us and the Germans/Eastern Europeans.

Another area, Eastern Mediterranean figures are lower than Western - Spain/Italy are high. Asian and Afro-Caribbean levels are low. Is this genetics, lifestyle or a combination - we need figures broken down by Ethnic background, as we have with heart disease and other issues. Only then will the picture become clearer.

Dave.

mrsD 06-02-2015 08:15 AM

There is one thing I notice on those maps. I changed the disease and also looked at diabetes.

That link is for DEATH rates from the title disease. Not incidence of the titled disease.

Death rates are always rather fuzzy, because the cause of death may be entered differently from the DIAGNOSIS the patient has.
For example... many die from infections, and that may be listed on the death data instead of the Alzheimer's.

Here is a link about INCIDENCE of Alzheimer's in Japan....
http://www.hindawi.com/journals/ijad/2012/956354/

While it is difficult to read the conclusion suggests that Alzheimer's is more common now in Japan approaching US figures.
Quote:

In conclusion, our systematic review shows that (1) there is an increasing trend in overall dementia in Japan. Although we cannot confirm definitively from the current study, the possible explanation of the increase could be a shift in health conditions among the elderly in Japan including the increase in diabetes mellitus in more recent years despite the plateau in decline in stroke incidence during the late 1990s; (2) the similar AD/VaD ratio found in recent studies in Japan with that of the US could be due to a combination of at least 3 factors: (a) shifting diagnostic criteria (more in line with US consensus diagnosis), (b) possible shifting in health conditions among the elderly in Japan (decline in stroke incidence, but increase in metabolic disease e.g., type 2 diabetes, hyperlipidemia, and atherosclerosis), (c) an increase in the proportion of the oldest old who had an historically higher prevalence of AD (as opposed to VaD) in Japan, and (d) regional variations (i.e., a north-to-south gradient in VaD) possibly due to large difference in dietary patterns.
So looking at the Diabetes part of the link, shows that DEATH from diabetes in the developed countries is low... but certainly not its incidence, as we hear every day is rising.


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