Hey all.

I still don't know exactly what to write here, but I was hoping the resident expert "mrsD" could help answer.

I have been experiencing significant symptoms for the past 2-3 years. Mainly: significant fatigue, all over muscle soreness, significant leg pain (when standing or walking), as well as diagnosed peripheral neuropathy in my legs. I also have notable anxiety and depression.

I have seen a ton of doctors, and over the last 2 months I have really been looking into lyme disease, but keep testing negative. I know the tests aren't accurate and it should be a clinical diagnosis, and was willing to accept this.

HOWEVER.... I just find out today that my vitamin b6 levels are off the charts (toxic). The range is 20-96 nmol/L, mine is 335 nmol/L! I don't take any large B6 supplements, just whatever is in my multivitamin (5mg per day). I understand B6 is also in food.

I looked up symptoms of Vitamin B toxicity, and sure enough, it matches a lot of my symptoms (by the way is there a complete list of B toxicity symptoms anywhere?).

I have read a parasite can cause this... Any idea on how to test for this? What parasites to test for?

I also have the MTHFR C677T mutation (+/-), hetero? But not the "other mthfr mutation". Im told this can affect detoxification etc....

At this point im so confused what to do.... I have NO idea how my b6 levels got so high. It doesn't seem like there is anything to "take" to lower them..

Any ideas?

I doubt you are toxic in B6. This is a very uncommon condition and only manifests when people take very high doses every day for months and years. 5mg a day is not high. It is generally accepted that over 100mg a day (and typically more) may increase risk of toxicity over time. If you have normal kidney functions, a water soluble vitamin is lost when in excess thru the urine.

Most of the cases published resulted initially from treatment of PMS syndrome with 500mg a day for years.

Did you get your B12 measured at the same time? Do you know that result? Folate?

If you took your vitamins on the day before and day of the test, your reading may show higher than the range. The ranges were developed from "normals" who DO NOT TAKE any vitamins. So naturally if you consume B6 in food, and/or a supplement you would expect to be out of range. This is not a "high" like a drug level high or disease state high.

Why did you have the test run in the first place?

A MTHFR mutation would involve methylation of B12 and folate failures.

B6 may flood the serum if the red cells burst when the sample is taken. (this happens with potassium tests too, which may show a false elevation from red cell ruptures).

Secondly you may show high if the lab tested wrong. This is common with tests that are not done routinely. Calibration of the machine may be off, due to a degraded standard sample.
For example, Quest labs in the US had TWO false calibrations over years, for Vit D...and published that fact. They did not follow proper protocols for accurate calibration of the machines.

So your test may be a lab error. It is more common than you think.

You can stop all fortified foods (like cereals, energy drinks, etc) for a while ..stop all vitamins containing B6 or complexes, and then get retested in a 3 months. B6 is stored for a short time in muscle as pyridoxal, but in 3 months most of that would be gone. Just about every person who comes here thinking they are "high" in B6, retests in the normal range later.

Just between you and me...your first post has a typo in it, so I am not going to reply to it. Your reported test result was a huge typo.
here it is:
http://neurotalk.psychcentral.com/post1151646-17.html

Here is a blurb from a good source about too much B6...
from http://ods.od.nih.gov/factsheets/VitaminB6-Consumer/#h8

I wouldn't worry about your reading at this time, therefore.
Very low B6 levels, can cause neuropathies too, and that is why some doctors test for it.

What are you doing for your MTHFR mutation? This mutation is far more critical for you at this time.

Welcome shawng.