That helps a lot thanks

--would not involve re-myelination to any great extent; the small fibers are only thinly meylinated, or in many cases unmyelinated, so repair-regeneration there is primarily axonal in nature--the re-growth and reconnected of the nerve tracts themselves.

Of course, even with larger fiber neuropathy that involves larger, more heavily myelinated nerves, axonal regeneration can occur under the right conditions. Repair of myelin sheathing can occur considerably faster (weeks/months) than repair of axonal fibers can, though (months/years). If axons are destroyed beyond repair, though, they won't produce myelin, either.

From the standpoint of recovery, the "best" scenario is to have a neuropathy that only attacks myelin but leaves the axons intact. But a lot of demyelinated neuropathies are hard to arrest, and a lot of them lead to "secondary axon degeneration" when the axons are left uncovered and unprotected by their myelin casings for long periods.

This is such an excellent question.

I'm trying to figure out "how to be honest with myself" on the exact same question.

My chemo neuropathy started exactly two years ago.

For the last 1.5 years it's been fairly level, only slightly improving at the point where I can't stand or walk for long periods and I curtail many of the things I used to do, along with zaps, foot cramps, slight numbness, occasional tingle flareups.

Due to other challenges, I am only now starting to really research and implement my neuropathy program which is a whole suite of stuff. This is a lot, a lot of work and involves taking greater therapeutic doses of stuff that I wouldn't normally take long term.

I ask myself, am I being foolhardy? Is it too late now? Can Chemo PN really improve after 2 years?

Is there still some realistic improvement I can shoot for?

Natalie

Patrick, your supportive and positive answer is so needed. I have sudden onset wrist and foot drop over the last 2months which has been devastating. It is nice to hear someone say "anything is possible" and I am so glad I found this group in my darkest hour. Thanks.

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Thanks, and I am usually a pretty negative person. I know people don't always trust doctors but one thing both of my neurologists told me is stay positive. If you're someone who prays, pray hard, if you meditate, do that longer, whatever. Much like recovering from cancer positive outlook does help the body. There is actually scientific proof of that. We're here a short time in the grand scheme and as bad as the pain from this is there are always those worse than us.

Stay strong!!!!

Thanks.

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