Like a salt crusted fish, my left hand. Not one wrinkle. Some of the extraneous skin around my nail bed looked white, like I was swimming, but as far as that swim wrinkle, no.

So, I don't know. I mean this is not a direct copy of that test, but it is pretty darn close, no?

It just has me feeling "huh", mostly because I know how I have felt all along. I am almost two years into massive changes. I have been waffling on trying gluten free for a few months, just to see if it offered some relief and I may just do that. It will mean I am not eating vegan for that period, as I don't see how I can pull that off.

I would love to see what other people are coming up with. I will test my right hand again in the morning. The are both equally bad, I think. My left always feels worse because I am right handed, or that is my line of thinking on the matter.

This is very interesting. I noticed that some are trying it on their toes. I'm wondering if it would show much there. My hands are more likely to show wrinkles if I'm in the water too long I think.

My feet are effected more then my hands so I'm wondering if this has an effect on results if I test it on my hands.

MrsD can you give your opinion on this?

I think you can assume the feet would be affected, if your hands are. My feet started way before my hands became affected.

When I finally got the thyroid hormone both improved about 80%.

Salt encrusted right hand looked the same.

When I was done with this test, I had hubby rub into my back shoulder some of the Aspercreme Lidocaine, as I had a spasm there that was driving me nuts. I also noticed that I had Tinel's in my right wrist badly as well. So I rubbed the cream into my inner wrist before bedtime. This morning the buzzing is gone and I can type MUCH better with fewer mistakes! So I am going to make the wrist my target nightly for a while. I just used a little bit.

IS there reason to bother with this test if your biopsy came back positive?

No I don't think so for the most part.

But some people here have had their PN improve and the later
biopsies show improvement too.

So you could do this test, yearly, on your hands and see if you
have some wrinkling occur, and then you might be one of the lucky ones to have improvement. (rather than another expensive biopsy.)

I Actually had 4% lidocaine aspercreme here. Put some on my finger and big toe for 30 mins and no wrinkling at all. So, that would indeed confirm the positive biopsy I received. Seems like this is a pretty good barometer.

Just tried it but only left it on for five minutes (no wrinkling). DIdn't realize you have to leave it on for 30 min and cover with tegaderm?? tape.

I did it...no wrinkles.