[LouLou1978]

Hi everyone,

I was diagnosed with SFN by skin biopsy in January by a professor in London. My results showed increased nerve fibers. I have had all the tests, even a lip biopsy for sjogens syndrome but everything has come back normal. Because of the increased fibers it was suggested in my biopsy letter that it could be neuroinflammation, so consultant has put me on 5 days prednisone infusion. I am just wondering how long it would take to feel any results, if this was to work.

Thanks

[en bloc]

You'll know by the end of the 5 days...probably within the first 2-3 days. How much will be infused? I have had up to 1 gram (1000 mg) a day for 5 days.

[LouLou1978]

hi enbloc, I have am having 500 per day. Hoping it will make me feel better by the end of the week.

[Healthgirl]

Originally Posted by en bloc

You'll know by the end of the 5 days...probably within the first 2-3 days. How much will be infused? I have had up to 1 gram (1000 mg) a day for 5 days.

How long does it typically last?

[en bloc]

The steroids itself don't 'stay' in the body all that long (gone within a week), but the benefits can last all month or even longer in some cases. It all depends on the cause of the inflammation and how fast the inflammation comes back.

[Neuroproblem]

Originally Posted by Healthgirl

How long does it typically last?

iT Depends on the disease, that is causing autoimmune or inflammation. some can be forced into remission, some can come back within a matter of days. prednisone itself can cause inflammation in some cases.

[mrsD]

Originally Posted by Neuroproblem

iT Depends on the disease, that is causing autoimmune or inflammation. some can be forced into remission, some can come back within a matter of days. prednisone itself can cause inflammation in some cases.

I would like to see some links that explain this comment of yours, neuroproblem.

[LouLou1978]

Hi yes please let me know about prednisone causing inflammation, I have never heard of this before, now I am getting worried.

[February]

Originally Posted by LouLou1978

Hi yes please let me know about prednisone causing inflammation, I have never heard of this before, now I am getting worried.

There is a prednisone induced myopathy that can happen with high dose, or long term use. I'm not sure about the inflammatory. I think the studies show it's more likely over 5 grams. Your well under that.

I agree you should notice strength within a few days. It will stay in you for a few days after you stop taking it as well. I think 5 days.

If you feel worse or side effects get too bad just call your doctor before deciding to tough it out.

[mrsD]

Here is an article that explains myopathy induced by corticosteroids:

http://emedicine.medscape.com/article/313842-overview

You can join Medscape for free, if you don't belong.

This process is not really inflammatory ..it involves certain growth factors, mitochondria and RNA.

Medscape has a strict copyright, so I cannot quote from there.