That's exactly why I had my primary put me on that drug combo over a year ago. Now I'm adding LDN to the mix too.

Thanks for the link Cliffman

Good article - lots of relevant information.

Thanks for the good thoughts. I'm trying to limit my time on here because as much as everybody is really supportive and helpful, it was bringing me down. I didn't find the answers I wanted ( people do improve) and I was spirally downward.

What is considered a LOW DOSE that is still high enough for nerve growth?

Low dose for PN is 10-25mg a day. But the study, as I answered you on the other thread does not provide much information on dosing for the nerve growth issue. I don't think anyone here has an answer to your question. Sorry.

I hope you don't mind I'll join the threat to ask a question:

I'm researching alternatives to GABA drugs, pregabaine made me twitch and cause involuntary movements only a week after taking it, forcing me to discontinue
I'm trying to deal with pain med free but it's not easy
I was consider Tricyclic antidepressants, but I have family glaucoma case (my dad) and personal episode of arrhythmia (that is quiet now)
Does it mean Tricyclic are of the table or a small dose used in PN wouldn't hurt that much?

I read about cymbalta and I don't think I want to go that road
As I understand there is not so many options left besides opiates that are effective in high dose

There is another anticonvulsant besides Lyrica and Gabapentin that is supposed to work well without as many side effects as Lyrica, It's called Vimpat. I have not used it but a friend of mine that has SFN said it had the highest efficacy of the 3. However if cost is a concern it can be as expensive if not more than the Lyrica.

Here's a link to a comprehensive medical article that includes all the pharmaceutical drugs and their efficacy ratings including the antidepressant pills. http://www.paulchristomd.com/wp-cont...%2012FINAL.pdf

Hope it helps..........
Cliffman

Just read about it and it looks it had no effect on GABA, would bee worth a shot!

Cost a small fortune indeed


Found that article, looks like it has cardiac risks, I don't think it's for me either

https://www.google.com.bo/url?sa=t&s...-GnrWFIPbcGFiw

I read about cymbalta too, I think I'll give it a shot if my case doesn't improve this year. When it works for people, it can work really well. Yes the withdrawal sounds hard, but risking a few weeks of being a mess for potentially years of good pain relief makes sense to me.

Hi Chris!

Sides of pregabaline freaked me out so I'm not that hasty to jump on cymbalta boat yet
So it's not only withdraw but what it can do to you while you're on it
I'll try trycilic first, I just really want to clarify if a low dose pose a risk of prolonging QT, as tachycardia is really the last thing I want to worry about right now
I'm very sensitive to anything that interfere with my heath rhythm

Haven't you though about combining low dose amitriptyline to your current lyrica?
Combination suppose to work good, maybe it won't you make so sleepy like last time
Or try nortriptyline instead