My wife has been suffering from perihperal neuropathy for a few months now. After a full neurological screening (spinal tap, MRI, blood work) it seems clear that the PN stems from what we both always thought: a toxic reaction to Azithromycin, followed by a week of Mirtazapin which worsened the symptoms a lot. I know neither of these medicines are mentioned here on the forum that often, but the correlation is extremely clear to both of us and I choose to trust our intuition in this (since all the predictions the doctors made have been false so far).

Three weeks ago my wife started on a low dose of Lyrica - 50 mg initially - and has slowly upped this by 25 mg increments. Today she's at 150mg (75mg morning/evening). The Lyrica quickly supressed the most painful symptoms and after about 1-2 weeks of treatment the PN had been reduced to slight burning and tingling, no more sharp pain. However about 3 days ago the burning and more painful ache started coming back and she feels the symptoms have had a slight increase every day since. I am unclear as to what might cause this. Do any of you have experience of Lyrica (or Gabapentin) at first working for the pain and then the pain coming back?

Also about ten days ago my wife started eating a daily regiment of supplements:
- B12 Methylcobalamin - 2mg (1mg morning + 1mg evening, empty stomach)
- Vitamin D3 - 2000 IU
- Magnesium - 250mg
- Omega 3
- Probiotics

I recall reading somewhere that sometimes when people start with B12 they get an increase in pain, could this be a factor? Or could it be that the nerves have started healing and thus are causing more painful sensations?

We also just got home Acetyl L-Carnitin, but the morning after the first 500mg dose is when she started having the increase in pain, so we stopped that out of fear it might be the root cause. Any input on this? Should she keep up the ALC?

Thankful for any help and input on any of these issues and questions.