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-   -   Has anyone done a fecal transplant? (https://www.neurotalk.org/peripheral-neuropathy/231375-fecal-transplant.html)

DavidHC 01-22-2016 11:43 AM

Kiwi, thank you for this. I appreciated it. I found it a few nights ago, and asked a friend to get me the article. As soon as he gets it to me, I'll read it. It is the only thing I've read that concerned me, even though it's n=1, though it's more like n=1 x4, since there were three other post FMT adverse outcomes. It is a reason to pause at least. I read about it here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365524/ and then read the original study. This is the relevant bit:

"G&H Are there any potential risks of fecal transplantation that clinicians need to keep in mind?"

"LJB Fecal transplantation is normally performed via colonoscopy, so the risks associated with colonoscopy will also apply to fecal transplantation, but these risks are minor and well known to endoscopists. Otherwise, there have been no significant adverse side effects definitely attributable to fecal transplantation. In the study we presented at the 2011 ACG meeting, we found that 4 of the 77 patients in our study developed some kind of immune disease following their fecal transplantation procedure. There was 1 case of peripheral neuropathy, 1 case of Sjögren syndrome, 1 case of rheumatoid arthritis, and 1 case of idiopathic thrombocytopenic purpura. While these adverse events bear consideration, I do not know if they were definitely attributable to fecal transplantation."

I'm not sure what to think. I think that the microbion affect immunity, so much of our immunity is/originates there, so though I get the caution of the physician, I think they need to realize this essential truth. But, again, I get his caution, as there's no evidence that the FMT caused the immune issues and these were all pretty sick people and the immune issues could have easily arisen from the initial infection and/or adverse impact on their microbiom, or even earlier and remained dormant.

But you're definitely right that it's worth considering, perhaps more seriously than the studies authors have done. :)

Edit/Addition: It seems all there is is the poster. I just read it, but want the published final paper, though I may have to contact the author. It seems like the PN resolved itself 6 months later and that the patient was already quite ill at the time, not just with CD. But still a note of caution, especially since there were three other autoimmune issues post FMT.


Quote:

Originally Posted by kiwi33 (Post 1194860)
DavidHC, I can't find any accounts of faecal transplants being tried (successfully or otherwise) for treatment of PN/SFN.

The title of this (admittedly n=1) case report poster may be worth considering http://www.pmrjournal.org/article/S1...918-6/abstract.


DavidHC 01-22-2016 12:39 PM

Yes, of course. Thank you. If I do it, I will do extensive testing of any potential donor. FMT has the potential to do great good or bad to the immune system, so great care is essential.

Quote:

Originally Posted by February (Post 1194941)
A lot goes on into clinical trials that you can never read about. There are many preliminary requirements, too many to list, on a case by case basis that are documented privately.

With this particular study, I would ask if I were safe from contracting campylobacter jenjuni or cytomegalovirus, two causes of Guillian Barre Syndrome. SFN is the worst thing until you compare it to large fiber, both sensory and motor, cranial, autonomic all together like in GBS. Please be careful.



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