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01-26-2016, 01:14 PM | #1 | ||
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Magnate
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Stillhoping: if there is celiac in your family, and you have low B12 and a positive anti-gliadin IgG antibody--though that antibody result is the least specific, it is the most sensitive, often showing up first--it might well be worth the endoscopic biopsy.
Low B12 can absolutely be caused by celiac/gluten sensitivity. The most famous celiac poster in the on-line world, Cara, AKA jccglutenfree, found out about celiac in her family through low B12 levels. There may be deficiencies in other vitamins/minerals as well as absorprtion of these is compromised. And, RunWriteMomHeal: that A1c level does correspond to a daily 100 or so average reading, but not a FASTING reading; that is the average of all your blood sugars over three months, including after eating meals. I'll bet your 12-hour fasting blood sugar levels are in two digits. Pre-diabetic A1c levels are considered to start at 5.7 (used to be 6), frank diabetes at 6.5. I think you're relatively ok there. Your 6.45 lower extremity intraepidermal nerve fiber reading is at the lower end of normal low, but not that low (about 20th percentile). The question is, what would it have been pre-symptoms . . .? |
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"Thanks for this!" says: | madisongrrl (01-26-2016), stillHoping (01-26-2016) |
01-26-2016, 02:21 PM | #2 | ||
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What do you mean by showing up first ? Is it possible that the rest of the antibodues will turn positive later ? or the symptoms will appear later ? I did the antigliadin IgG Ab test about 15 years ago. I repeated the other antibodies tests but not the antigliadin IgG because it isn't included anymore in the celiac screening here. Besides that test 15 years ago all the other celiac antibodies were normal. Can a positive gliadinn IgG Ab indicate other diagnosis then celiac ? |
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01-26-2016, 04:40 PM | #3 | ||
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Are you looking at a chart for women in their 30s? And where did you find the chart? Thanks ! |
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01-27-2016, 08:03 AM | #4 | ||
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Magnate
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--I've never been able to find any material that's been publicly published that indicates difference in intraepidermal nerve fiber density norms by age and gender.
The original norming figures from Johns Hopkins' research did indicate a slight diminishing in the numbers with age but I haven't found all that much that is specific as to how much. Some other studies later on did not find significant diminishing of nerve fiber density with age, though. (This does seem to depend on what groups are chose for comparison. There is also some evidence of racial differences in nerve fiber density, though not all studies point that way.) This first paper summarizes the norming figures on which the skin biopsy protocols are still based (it was published in 1998). Notice the means and standard deviations (which is to say that your thigh figures are below the average but well within the first standard deviation, by my calculation at about the thirtieth to thirty-third percentile): http://www.ncbi.nlm.nih.gov/pubmed/9865794 This one, used by Aetna to provide indications for skin biopsy, summarizes a lot of other research since then (but by no means all): http://www.aetna.com/cpb/medical/data/700_799/0774.html Now, as regards the celiac testing, an elevated IgG anti-gliadin can be seen in a number of other autoimmune conditions; it is not as specific as the anti-gliadin IgA or especially the anti-transglutaminase IgA, which is the most closely associated with villious atrophy. However, those with gluten sensitivity often show with anti-gliadin IgG markers first. There is even some reports--mostly from Finland and England through the work of Dr. Hadjivassiliou--that those with isolated anti-gliadin IgG titres are more likely to show neurologic indications of gluten sensitivity, You may know that much of the work on gluten-mediated neuropathy has come from Cornell and the work of Dr. Latov, Dr. Chin, and Dr. Peter Green at the Celiac Center of Cornell/Columbia/Presbyterian, building on the Johns' Hopkins' work. One of the best places to read about all this is through the Gluten File that jccglutenfree (Cara) has put together. It is linkable right though our own celiac section here: http://neurotalk.psychcentral.com/thread1872.html |
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"Thanks for this!" says: | RunWriteMomHeal (01-27-2016), stillHoping (01-27-2016) |
01-27-2016, 09:04 AM | #5 | ||
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And this has nothing to do with anything, but I wonder if people's naturally different levels of nerve fiber density has anything to do with the wildly different perceptions of pain and pain tolerance different people have. That would be fascinating... |
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01-27-2016, 09:17 AM | #6 | ||
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