I was on Lisinopril for 8-9 years, never knew it could cause PN symptoms.

Some people are genetically prone to this reaction. Partially inactive C-1-inhibitor allows the bradykinin to build up. But people with normal complements 3,4 and C-1 inhibitor may be less likely to react to elevated bradykinin levels. Bradykinin, remains in the cells until an "event" triggers it. It can be prolonged stress, trauma, infection, surgery etc. Bradykinin then comes out of the cells and causing diffuse inflammation, in response to the stressor. People with genetic problems in manufacturing the C-1 inhibitor are the ones to have long term problems with the ACE drugs.

These drugs were synthesized from snake venom.

Thanks for the information regarding Lisinopril and Atorvastin. I had quit taking these months ago, in part due to budget issues. Since my bad cholesterol is going down, and the good going up, and I have normal blood pressure I will continue no taking them.

What I am taking is 10mcg Butrans patch, Invokana, Duloxetine, Gabapentin and I am still having problems controlling the incessant pain/tingling in my feet/toes.

Are there supplements that can help heal the nerves? Lessen the pain?

Many here go to low carb diets as sugar doesnt help inflammation. Some folks go over 3000mg/d with the Gabapentin. I used Mortons Epsom Salt Lotion on the tops of my feet and was able to use bedsheets again. Epsom Salt baths for the feet helps others. I have used many supplements but tied them to general improvement not instant help, sorry. Wait, getting b-12 up to around 900 helped w/leg strength Good Luck, Ken in Texas.

Diabetics lose magnesium thru the urine. So supplementing with it may help with the circulation to the toes.

You can soak in epsom salts soaks in lukewarm water, or use a magnesium lotion...(Morton's was recently discontinued).
There is a magnesium cream still available... Kirkman brand.

http://www.amazon.com/Kirkman-Labs-M...agnesium+cream

200mg a day on the lower legs/ankles and tops of feet may help the blood supple to the toes. (100mg on each leg)

We have all been protesting the Morton's decision but it will probably be useless. That lotion was a miracle for me and many others here. I am so angry, that I won't ever buy a Morton's product ever again!!!