This MG case is interesting. Thanks for sharing. Thank you also for the link to D2. I'm increasing magnesium and staying with D3 for now, but I really want to increase my doses. Let's see if I can get rid of the insomnia. If not, I'll switch to D2. What I found interesting in the study is that her numbers dropped and she came out of remission when it was stopped, particularly when cholecalciferol was stopped as the article notes. So they were giving her D3 in such insanely high doses. I wonder how I would respond to such doses when I respond so well (minus the insomnia) to such low doses.

I wouldn't go that high as in the article...you would need blood work for calcium at the high doses. But our MS patients do take quite a bit of D also with medical supervision.

The article is to illustrate that high dosing may be useful....but I wouldn't do it yourself.

For example, I met a patient with severe autoimmune kidney disease, whose nephrologist had him on 13 fish oil caps a day.
This was based on a Chinese study showing the treatment for this
difficult malady...which was putting him close to a kidney transplant. The fish oil worked and his kidney healed up over a year and he was very enthused about it and loved to talk to me about it. But I could never recommend this on this board or in my professional career to others. But it did illustrate that sometimes drama and high dosing works. This patient was under supervision by his specialist physician at all times. I did however get him to try going gluten free, and he did and solved his GI problems too.

Oh no, I would never do so without blood work and the right diet, for sure. Supervision and serum checks would be essential. I'm not there yet, but I do wonder. I certainly would take it before Prednisone. Anyway, we'll see what happens.

That story is quite interesting. A family member is leaking protein and has some issues with his kidney or kidney tissue, and I only recently convinced him to take 1000-2000 IU of D3. He takes fish oil, but not that much.

I think my question might have gotten lost in the thread, though excuse me if you answered it and I missed it. Should I stop supplementing with D3 before taking the blood test? If yes, how long before? Thanks.

I really don't know. I would think that since the D is so different from other vitamins, and minerals, that has not appeared in the studies.
If you don't stop a high result would at least show you are absorbing it. But since it is removed quickly from the serum, stopping it will show that it is not there but there is no way to show what the tissues have.

Doctors do evaluate patient responses and value that sometimes over test results. Nutrients do not always behave like drugs, as far as test results go.

Thanks again, Mrs.D. D is just so complex and we don't know quite a lot about it. I understand and agree. I've read a great deal about it the last little while and I've not seen anything on this issue either. But this "If you don't stop a high result would at least show you are absorbing it" is exactly right. This is what we know and so I'll keep taking it. Also, we already know that I'm feeling the benefits, so there's that too.