This is quite interesting and makes perfect sense. If anyone has further studies, please share, especially in human models:

http://ajpgi.physiology.org/content/294/1/G208

this certainly make sense for bowel disease, and for celiacs, because this is what happens in people with celiacs.

These two reviews are worth a read in this context;

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955835/

http://bmcgastroenterol.biomedcentra...876-014-0189-7

--check The Gluten File for a lot of papers on the role of VitaminD in immune function and intestinal permeability.

The Gluten File was originally put together by Cara, AKA jccglutenfree (her journey to learning about gluten and celiac is fascinating in its own right, and she was doing this well before celiac became a cause celebre--indeed, her work may have helped to set greater awareness of celiac in motion some two decades ago). Over time many have added to it and I think it is still the best database out there for poking into the more obscure corners of intestinal malabsorption issues; for instance, she was the first one to compile in one place a lot of the important work of Dr. Hadijvassiliou, who examined the neruological aspects of gluten intolerance and posited a different genetic profile for those who might have neurological symptoms, as opposed to gastric ones, early in the process (with all the attendant misdiagnoses that might entail).

http://neurotalk.psychcentral.com/showthread.php?t=1872

I did. That's where I found the article I posted above, but I wanted to share it and look for more and more recent things on this particular issue.

Fascinating. I'll keep exploring the file. I looked through it yesterday and read a number of things.

Thanks for the links guys. Genetic testing shows that I have a mutation in the VDR taq gene. And I have suffered with IBS for most of my life. Probably time for me to look at this issue again.

The problem with genetic testing and looking at all the methylation related mutations you can have is that there are so many positive and negative interactions between the various mutations. So, if you have multiple mutations like I do, its hard to know what to do. The specific dietary supplementation necessary to "fix" one issue might be contraindicated for one of the other issues.

My issues had kind of settled down for a while, but are acting up a bit again. I was taking a bit of a break from making health research my second job. But, I think its time to try and re-examine my approach to managing my health. But it does get depressing when you find so many potential problems but so few potential solutions.

Thanks, Kiwi. I located and read the first last night and meant to post it this morning, but you beat me to it. I haven't yet read the second, which I'll do now.