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Old 04-05-2016, 08:08 PM #11
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Mrs. D - I just learned that I have the MTHFR Mutation. I'm taking methyl b12 supplements; does this mean I also need a different form of folate? As an FYI: My most recent blood test showed:

Pyrrole Disorder
High Histamine
Zinc Deficiency
MTHFR Mutation
Elevated Copper

I failed my second EMG that concluded evidence of a length dependent axonal sensorimotor neuropathy. A cat scan of my lungs showed evidence of inflammation - although I do not have any congestion. They want to repeat in 3 months.

I am feeling much better thanks to meds: Cymbalta, Neurontin and low dose of Xanax. Are there any nutrients you can recommend? Any additional testing, or do I just need to wait and see what develops?


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Originally Posted by mrsD View Post
What does your B12 results say? Don't have them, then it is time for testing.

The big three items IMO for PN are
methylcobalamin
Folate (perhaps methylfolate)
magnesium

The 4th is Omega-3's.

As the days and weeks and months pass on these forums more and more patients are getting the DNA testing for MTHFR mutations and finding they have this genetic problem. When these common factors are present, you cannot methylate (activate) folic acid and cobalamins in food.
You may have difficulty making certain neurotransmitters properly. The testing is not expensive.

more here:
http://mthfr.net/
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Old 04-06-2016, 08:23 AM #12
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you are showing lots of concerning issues. I think you need a good doctor to interpret your goals and treatment.

That high histamine certainly can cause many symptoms.

you do have to give your methylfolate and methylcobalamin time
to work.

There is a condition that causes elevated biogenic amines (of which histamine is one). That is called Carcinoid syndrome, and does also affect the lungs. You can get tested for this, to rule it out. Doctors sometimes overlook this possibility.
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rec60661 (04-06-2016)
Old 04-06-2016, 09:29 AM #13
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Very appreciative of your reply; I did some quick research and will follow up for testing on Carcinoid syndrome asap. It looks like there are a few medical centers with docs who are aware of the condition. Also, the high histamine test result is from Pfeiffer Medical Center. A friend of mine recommended that I get a nutritional assessment from them and I'm glad that I did. Much more thorough and they prescribe compounded nutrients. I'll also follow up with them.

Thank you again!!

Quote:
Originally Posted by mrsD View Post
you are showing lots of concerning issues. I think you need a good doctor to interpret your goals and treatment.

That high histamine certainly can cause many symptoms.

you do have to give your methylfolate and methylcobalamin time
to work.

There is a condition that causes elevated biogenic amines (of which histamine is one). That is called Carcinoid syndrome, and does also affect the lungs. You can get tested for this, to rule it out. Doctors sometimes overlook this possibility.
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