[QUOTE=JoannaP79;1212540]Hi Sylvie,

Its interesting you say this. I managed to get on relatively well with SSRI's years ago. I stopped for a number of years. (After I had my child my SFN hit and it went hand in hand with depression / severe anxiety at exactly the same time. I am convinced there is a physiological inflammatory cause behind feelings of depression.) I tried SSRI's again and I have now become hyper hyper sensitive since SFN hit. To the extent that after only one tablet on one day I vowed never to try it again. I was almost shaking under my duvet in bed in fear all day - it was bizarre. I'm therefore very cautious about any type of anti depressant but am desperate for something to help me through this. I feel alot of the depression is because of what has happened to me physically and I therefore feel like there is no point even trying to address the depression medically - but I have got to try something even if it is just a sticking plaster. If it helps numb the emotional anguish, I will try it.

I am going to look into Lactimal. I havent heard of this. My neuro and I both feel my SFN is inflammatory,...


Hi Joanna,

Yes, I , my shrink, and my new neuro all think there is neuro-inflammation going on with Mr (especially with my acute onset of SFN and depression).. Lactimal (lamotigine) is especially good for this....I'm on my reader now and can't cut and paste, but there are good articles out there.. You can Google key words "lamotigine" and SFN, and separately lamotigine and depression. Apparently lamotigine not serotongeric at all...I've had no side effects so far (except edema..and there may be other reasons for this related to my autonomic neuropathy, which is also showing improvement)...as I wrote I titrated up 25 mgs every two weeks, and I plan to stay at 100 mg...less than half the usual therapeutic dose.

Read all about it.....I was really resistant to the idea, but I'm so glad I relented and tried it.

I'll be curious to see how it affects you if you try it!

S