[Dorothy]

I am doing something wrong! First let me tell you how I take my meds and suppliments

Morning
50 mg of atenolol
360/12.5 diovan
400 mg of glucophage
400 mg of neurontin
estratest
and the following suppliments
500 mg of ancyl-l-carnitine
1 a day multi vitamin
600 mg of calcium

Lunch
800 mg of neurontin
1 flax seed/ evening primrose oil
200 mg of chromax
400 mg of goji berry

Dinner
800 mg of neurontin
400 mg of glucophage
3-6-9 fish oil

Bedtime
1200 mg of neurontin
1 b_50 complex
B12 - 5000mcg
200 mg of co-q-10
600 mg of alpha lipoic acid
400 mg of magniusum oxide
600 mg of clacium
1-evening primrose and flaxseed

Sometimes before I go to be I take 2 aprin to help the pain

On my last visit to my neuro, he decided my neuropathy is not caused by diabetes ( he said my numbers are too consistent) He sent me for tet to see if it could be Sjorgens or Celiac.

Here are the results...I can't understand them. "B6 elevated at 60.5 ng/mL (normal 3.3-26.0) Serum immunofixation(IFE normal with low IgG 681, low IgA 58 and low IgM 21) Gliadin antibody panel (all negative) and sjogres antibody Ro (negative) and La (negative)"

His notes also tole me to stop taking anything with b6 in it.

Can someone explain what my results are and tell me if the is anything to change about my vitamins. Are they timed correctly or a problem tking them wogether.

Dorothy

[Brian]

Hi Dorothy, i would check how much B6 is in your multi vitamin and your B complex, i see your taken glucophage have you had a 3-5 hour glucose tolerance test yet, normal blood tests are useless for checking prediabetes.

[Dorothy]

Yes I did have a glucose tolerance test but my numbers were normal. I believe they felt I would become diabetic...7 years later I am still normal but blaming my neuropathy (which apparently is severe) on diabetes was just easier...now they decided to look further

My complex has 50 mg of b6 (P-5-3 formule) and my multi has 4mg.

[Aussie99]

In relation to the BP meds, I was advised not to take any other meds or supplements an hour and a half to two hours after my BP meds as others can interfere with them. BP meds seem to work better now.

[mrsD]

we are leaving for the summer.

I did post to you on the other thread, about the magnesium oxide.
This form of magnesium is almost useless. You need to find another.
If you check your other post I have details, there.

Your Diovan/HCT depletes magnesium and thiamine. I don't think there is enough thiamine in a standard OTC multivit to make up for this loss. So you can consider some thiamine separately. 200mg/300mg daily in divided doses.
If you decrease your B-50...at least supplement folic acid and thiamine instead.

High B6 can imply poor conversion to activated P5P... this is not well understood, but high serum levels imply your muscles and liver are not taking it up, from food or your multi. Your estrogen should be depleting B6 as well.
So this is a puzzle.

See you in Sept.

You can read about nutrient depletions and drugs in these references:

Drug-Induced Nutrient Depletion Handbook by Pelton and LaValle RPhs.

And The Side Effects Bible by Frederick Vagnini MD.

[Brian]

Dorothy I am glad they that are looking into it further for you, but 7 years years later :confused a bit slack, in my book.
The B complex i take in the morning as it gives me an energy boost, with the the b12 it shouldn't matter what time of day you take it, it's better taken on an empty stomach though, i take mine mid morning but that's up to the individual.

I am sure someone will be along shortly to explain all that technical stuff [explainSerum immunofixation] etc.

[glenntaj]

--is worth looking into, but your intake levels don't seem high enough for you to be suffering neuropathy from that; most reports of B6 overdose neuropathy involve doses WAY in excess of what you are reporting:

http://www.neuro.wustl.edu/neuromusc...yridoxineintox

While having an immunofixation electrophoresis (IFE) that is clear of rogue monoclonal antibodies (m-proteins) is a good thing, your immunoglobulin levels across the board are indeed a bit low for an adult. This can be due to a lot of things, most commonly Common Variable Immunodeficiency; more investigation into this would be a good idea, to see if you have particular deficits within certain immunoglobulin subclasses that are driving the overall numbers down. (Do you get a lot of bacterial infections?)

While the gliadin test was negative, an anti-transglutaminase assay should also be done if gluten sensitivity/celiac is supected (more specific, though less sensitive, test than than the anti-gliadin). Another important point here--these tests tend not to be as accurate in those who have low immunoglobulin levels (the anti-gliadin and anti-transglutaminase antibodies are IgG and IgA class). And--there have been plenty of people with "seronegative" gluten sensitivity; in fact, as Cara's Gluten File (you can find links to that in the gluten forum here) indicates, people with primarily neurolgoical symptoms of gluten intolerance are more likely to be seronegative.

It's similar with Sjogren's; there are plenty of people with symptoms who are seronegative for those characteristic antibodies. (Have you had anti-nuclear antibody/rheumatoid factor tests run, for connective tissue/vasculitic syndromes that may result in neuropathy?)

I agree that it often takes a 3-5 hour glucose tolerance test, with levels taken every half-hour, to show imminent or developing impaired glucose tolerance, which can certainly lead to neuropathy symptoms well before frank diabetes would be diagnosed. But, too many doctors will attribute neuropathic symptoms to that without a real thorough search for other possiblities.

The Liza Jane spreadsheets at www.lizajane.org are a great way to see just how comprehensive your work-ups have been, as well as to track the patterns of your test results over time.

[Dorothy]

Well to answer your question...I don't usually get bacterial inffections..if fact, I work in an elemenatary school where bacteria can run rampid. I have not had a sinus infection, or upper respiratory infection or anything for years.

This is not the first time he has tried to figure anything out. This time I just don't get the results.

[ConsiderThis]

Hi, the only thing I would mention, and this isn't perfectly on topic, is that with the aspirin it might be good to have a cracker or something...

There was a dynamite article in the Chronic Pain forum about how 5 to 6 thousand people a year die from aspirin and Ibuprofen, due to the stomach damage they can do.

Ages ago an MD who was also a homeopathic practitioner told me to always have a cracker, that was enough, she said, to keep the over the counter pain killers from hurting me.

Also, I'd take more magnesium than calcium...

[Brian]

Dorothy, I am just wondering why are you taken the 2 doses of glucophage daily when he said your levels are ok.