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Old 03-19-2017, 08:36 AM #21
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Just to clarify:

methylcobalamin supplements are 1mg (1000 micrograms) and 5mg (5,000 micrograms) per tablet.

I don't think B6 is tested for in the DNA testing. It is the B12 and folate that are part of the MTHFR results.

B6 is tested for in serum blood tests however.

Do stop all supplements for several days, before any blood testing. B6 remains bound to muscle for several days in the body and may show high because of that if you took B6 supplements for a while.
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Old 03-19-2017, 08:40 AM #22
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@MrsD
Thanks for the quick response! Do you have any information or experience about fingernails?

Yes, I'm an idiot, I forget sometimes which medications are measured in micrograms or milligrams. I did mean 5mg!

I've never taken a B6 supplement (other than in a multivitamin perhaps, over 4 years ago). That was the cause of this thread initially, as I was so confused about my elevated B6.

I hope you're doing well and thanks again.
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Old 03-19-2017, 09:36 AM #23
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I don't think much of the finger moons vs B12. I've never had moons on my fingers, and only small ones on my thumbs.

I had a very robust B12 level, my first test, over 15 yrs ago before I ever tried B12 myself. (849 pg/ml).

I think genetic inheritance of skin, and hands, are probably the cause of the variations.

Low B12 does lead eventually to anemia however.
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Old 03-23-2017, 11:18 AM #24
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Paresthesia in my hands is worse (whether caused by PN or not) as it is now constant. I have red fingertips quite frequently. It really does feel like fluid retention. There are many possible causes. A moon has returned on my right middle finger, which is the one with the largest bump on the nail. I tried stopping all supplements slowly and it seemed paresthesia did not get better.

I used to think it was fluoxetine and cold weather but as it is warmer now and fluoxetine is one of many probable causes I'm lost again. I am reducing fluoxetine slowly but it could take over a year to do so safely. Hopefully will get a prescription tomorrow for all the blood tests I need. I'll keep you all posted.
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Old 06-20-2017, 04:44 AM #25
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I am new to NeuroTalk, but I too have been where you are with PN and paresthesia on my face and head. My symptoms started about 17 months ago with strange numbness over my left eye and burning feet and hands. I got all sorts of lab work done and an MRI to rule out MS. The only abnormal test results were high B6 and B12, despite the fact that I was only taking a simple multi vitamin with just the RDA of both.

I stopped taking the multi vitamin and eventually my B6 and B12 levels returned to normal, but the symptoms have persisted. I decided to add my story and two cents in because I was curious if you ever had MTHFR testing done? Also, I am wondering how you are doing these days. Any relief from the PN?

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Old 08-01-2017, 04:23 PM #26
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I'm sorry I haven't been here in a while. I managed to eradicate my PN and paresthesia. Here's what I did but it is hard to discern what the major cause was. I've managed to make some of the symptoms return by taking zinc or B12 too often:

I limited zinc supplementation to once or twice a week
I introduced a vitamin B1 supplement once a week
I take vitamin B12 now once a week (my first blood test was 260,0 pg/mL, and when I had a test at the end of March 2017, it was 992,0 pg/mL)

Fluoxetine withdrawal is going slowly but there was no change to the dose at the time I noticed an improvement. There is also a hypervigilance factor that applies to my PN - now that I returned to this forum, and am writing about it, I am sensitive to tingling in my feet and hands. I haven't noticed anything for months. Hypervigilance and anxiety are major factors in my case and may be significant in even severe cases of PN.

I will update later this year when winter hits, to see if temperature has any effect, even though I had argued that warmer weather seemed to make things worse!

@NewCreature I'm so sorry it took so long for me to respond. I am very happy that you got your B6 level within the normal range. Your B12 level may be worth mentioning in a thread as its reduction hasn't resulted in you getting any relief from PN symptoms. It may be worth continuing to supplement B12 alone. I would avoid B6 supplementation. I did not get MTHFR testing done yet.

My situation with medication: fluoxetine and levothyroxine, means that my body is not functioning normally. There are iatrogenic changes that need to be addressed before I can get a good picture of what my body is really up to. However, genetic testing would of course yield the same results whether I was on such medication or not but I guess I've put it off until I can reduce my fluoxetine to much lower levels first.

How would you rate your paresthesia and PN out of 10 in terms of intensity? Do you ever get some relief from it at certain times of day or with certain activities? I never rated mine as severe but it definitely caused me discomfort. Are there any supplements you are taking still? It may be worth looking at those and starting a thread here asking for advice.

Feel free to keep posting in my thread though
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Old 08-05-2019, 01:45 PM #27
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I know this is an old thread, but after reading the whole thing, I find many similarities to @Kittygiggles. I was recently diagnosed with a rare genetic condition called hypophosphatasia, which can cause high levels of B6 amongst other symptoms. I landed on this thread because I was looking at the symptoms of high levels of B6 and possible solutions. While hypophosphatasia is rare, it might be worth looking into it. The genetic testing for this condition is quite expensive and most doctors have never even heard of it, but if that's not possible, the only other indicator is a low level of ALP, which in included in a liver function panel. I'm not sure if this will help, but I figured I'd put the info out there in case anyone wanted to consider other possibilities.
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Old 09-16-2019, 07:51 PM #28
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Hi GfxLgd

Welcome to NeuroTalk .

This information about hypophosphatasia may help you Hypophosphatasia - NORD (National Organization for Rare Disorders) .

You could also introduce yourself in the Rare Disorders forum here (https://www.neurotalk.org/general-he...are-disorders/) . Other members may be able to offer you good ideas there.

All the best.
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