I am posting my latest blood work results for my PIN which seems to have gotten worse this past year, I've had it for about 20 years now mostly in my feet. It seems to be progressing to my ankles and calves.

I would love to have your input on the results of my blood work. I'm mostly concerned and confused about the B6 because I don't know if I should take it as a supplement because too much or too little is not good. I am definitely increasing vit. d and taking Benfotiamine three times a day. Also should I take B12?

I stopped taking these vitamins for about 6 months because I thought I was taking too many. This blood work was taken about a week ago.

Thank you so much for your help.

Component Your Value Standard Range
Vitamin B6 78.1 nmol/L 20.0-125.0 nmol/L

INTERPRETIVE INFORMATION: Vitamin B6 (Pyridoxal 5-Phosphate)
Pyridoxal 5'-phosphate measured in a specimen collected following
an 8-hour or overnight fast accurately indicates vitamin B6
nutritional status. Non-fasting specimen concentration reflects
recent vitamin intake.

Component Your Value Standard Range
Vit. B1, Plasma 48 nmol/L 70-180 nmol/L

INTERPRETIVE INFORMATION: Vitamin B1, Whole Blood
This assay measures the concentration of thiamine diphosphate
(TDP), the primary active form of vitamin B1. Approximately 90
percent of vitamin B1 present in whole blood is TDP. Thiamine and
thiamine monophosphate, which comprise the remaining 10 percent,
are not measured.

Component Your Value Standard Range
Vitamin B-12 806 pg/mL 211-911 pg/mL

Component Your Value Standard Range
Vit D, 25-Hydroxy 47 ng/mL 30-100 ng/mL


Deficient: <20 ng/ml
Insufficient: 20-29 ng/ml
Sufficient: 30-100 ng/ml
Potential for Toxicity: >100 ng/m

Best Regards,
Rosie33

I don't see anything outstanding in your tests.

But you could try some things:

You could up the B12 a little and see if that helps. Only use the methyl form called methylcobalamin and at 1000mcg (mg) for a couple of months and see if you feel any improvement

It might prove useful to have the DNA test from 23 and Me...to see if you have any methylation errors. Over time here we've seen people testing positive for mutations on that test. One poster here Janieg had a big surprise from her test showing an omission of one gene involving the B vitamin Biotin. She is the first:
https://www.neurotalk.org/1238782-post301.html

Biotin is carried in the body by a transfer carrier molecule called the multivitamin transporter:
Sodium Dependent Multivitamin Transporter (SMVT): A Potential Target for Drug Delivery

Biotin is only one nutrient using this system. It may be bumped off by other nutrients, and all of them may be affected by others and a genetic error. So I think further research will reveal interactions with this transporter.

If you have the MTHFR mutation (there are 25 of these BTW) you will need methylfolate in addition to the methylB12.

Consider a food intolerance irritating you. MSG in processed foods irritates me significantly. There are drugs like statins and fluoroquinolone antibiotics which are neuropathy triggers among others. The nightshade food group is very irritating to some people. Peppers, hot sauces, even paprika and potatoes (which have solanine in them) can cause burning in some people.

If you have some error in your mitochondria...supporting those energy factories, can help. Foremost is l-carnitine. The HIV community knows this, and has been using it for decades now.
This nutrient is made by the body, but perhaps this fails with age or various toxin, drug damage as well,so using this may help.
Start at 250mg a day of acetyl carnitine, and raise by 250mg as needed after a week or so, up to 2 grams a day in divided doses.
Biotin up to 10mg a day works with the mitochondria too.

There is also Vitamin E. We have had one poster who posted about low impacting PN. This vitamin has little connection at this time here, but I am thinking that it can't hurt to try it using natural tocopherols in 400IU dose daily. Vit E works with vits A and C and works as an antioxidant to keep cells from damage.