My PN is in my hands only and is almost certainly a consequence of when I used to abuse alcohol.

Perhaps you could consider decreasing your alcohol intake?

The fact that things got better (Twice) with the Metanx and extra B12 hints that you could have issues with absorbing B12 or folate. Your body can store quite a bit of B12, so if you had the "tank topped off" you could have gotten by for a few years before it dropped to a dangerous level again. Did you ever have B12 testing done?

The neurologist that did my blood work never went over the results with me. They drew about a dozen vials of blood total over two appointments so I would hope he did check B12. A couple of years ago I requested a copy of my blood work and never got a response. Next time I am in Knoxville I will stop in and wait while they copy them. If nothing else I will have a 2014 baseline to compare any future tests.

He did prescribe the Metanx and I remember him saying that it is used in diabetic neuropathy and can be beneficial in idiopathic....sounds like it was a educated guess that at least for me was correct.

As the neuropathy advances, damaging more nerves, is it possible it just takes more B12 to slow it down? Until that is when it gets to a point that B12 can no longer stop it?

OP: A good friend with decades of neuropathy and mostly from statins and cancer burning surgeries..is feeling a lot of relief since taking Grape Seed Extract now for about 7 yrs or so..she took gabapentin for years and all it's side effects.

Personally I have some neuropathy from hip replacement surgery and in recent years staph infection in knee and the drugs and arthroscopic cleaning out the docs did.

I use Vicks salve on my feet night and day with socks, of course. I have been taking Grape Seed Extract about 23 yrs long before this damage.

There are so many possibilities for this nerve damage stuff.

Which grape seed extract do you use?

I've used many over all the years and like the price and quality of Olympian Labs 200mg capsules...Swansons has a good price and ebay too. I'm consistent as it has so many benefits.

Ok thanks, I'll add it to my supplement regime and see if it helps.

DishRag, Do you still Run?
One of the symptoms I noticed before my diagnosis is that one day I felt like I had no control over my legs and I could not run. I can still cycle and walk OK. I am going to try running on the treadmill and see if I can find a pace that is comfortable.
I feel like my balance is off but I don't know if that is the PN or the meds.