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DavidHC 10-16-2018 01:00 PM

Hi!

It's been so long! I hope you're doing alright.

Thank you. I appreciate that. It's definitely working for me, but so far it has been more of symptoms treatment than healing I guess, though it's still too early to tell and I can't be sure even now. It may be helping me in ways that are not obvious to me. I hope it can help you too if you end up trying it!

Apollo 10-16-2018 05:23 PM

Hello David, and thank you for your outstanding work here! This is one of the best threads ever posted within this forum. Indeed, I am a long-time sufferer with most of the symptoms you have, and mine are a result of Lyme Disease with its most common coinfections, Babesia and Bartonella.

I developed my first symptoms in 2005 at age 45 and now, at age 59, I have many years of education in both Neuropathy (and in my own case Small Fiber Neuropathy), and Lyme disease, too.

Indeed, having Lyme has forced me to literally obtain a medical education!

I have been on and off this forum for many years, during which time I was very grateful for Mrs. D. and her outstanding guidence (and I hope she is doing better?).

David, I would like to chat with you directly about the topic here, and what is the best way to do so?

Many thanks!

David

Apollo 10-16-2018 09:18 PM

Hello again, David!

I am rapidly coming up to speed on CBD and its various forms and, again, many thanks for your outstanding posts!

OK, questions ...

As a 59-year old male who weighs 180 pounds (20% over my ideal weight), and suffers primarily from Lyme-related SFN (and cervical spine issues), what oral capsule dosage (in mg) from a vendor such as "Bluebird" or "Fully-Activated" would you recommend for potential pain relief?

Specifically, Bluebird sells 15 mg capsules (quantity 30) for $40.00, whereas "Fully-Activated" sells 30 capsules ranging up to 105 mg of CBD at prices of $180.00 for the 105 mg (gasp!).

I am someone who wants to simply pop a capsule rather than having to play compounding pharmacist (grin).

Also, is the CBD best absorbed with or without food (or does it matter)?

Many thanks, and I look forward to your comments!

David

Apollo 10-17-2018 09:40 PM

Hello all!

I ordered a 30-day trial of "Full Spectrum CBD" capsules from "Fully-Activated" in Colorado, after a long and productive chat with its owner, Nick.

I will take a total of 90 mg daily in two-divided doses for my various Lyme-related neuropathies (and aches and pains), and then report back here. I am currently not on any other medication, so I make an excellent test subject.

We arrived at 90 mg in total daily, as it appears that an effective dose is one-half of your body weight daily (and I weigh 180 pounds). I will also take it on an empty stomach.

I did a lot of research in the last 24-hours and, needless to say, am very impressed by the potential of the cannabinoids! These suggest a whole new era in pain management, and I look forward to taking my first dose!

David

DavidHC 10-18-2018 09:48 AM

Hi David,

Nice to meet you! I'm glad you're so proactive about healing yourself. Many of us have no one else to help us, certainly not conventional medicine. But it seems like you've done plenty of research on that front too.

I'll send you a PM and we can chat online if you like since you have lots of questions it seems.

It looks like you're well on your way with CBD. :)




Quote:

Originally Posted by Apollo (Post 1268781)
Hello all!

I ordered a 30-day trial of "Full Spectrum CBD" capsules from "Fully-Activated" in Colorado, after a long and productive chat with its owner, Nick.

I will take a total of 90 mg daily in two-divided doses for my various Lyme-related neuropathies (and aches and pains), and then report back here. I am currently not on any other medication, so I make an excellent test subject.

We arrived at 90 mg in total daily, as it appears that an effective dose is one-half of your body weight daily (and I weigh 180 pounds). I will also take it on an empty stomach.

I did a lot of research in the last 24-hours and, needless to say, am very impressed by the potential of the cannabinoids! These suggest a whole new era in pain management, and I look forward to taking my first dose!

David


MCEC5 10-20-2018 01:47 PM

Quote:

Originally Posted by Apollo (Post 1268781)
Hello all!

I ordered a 30-day trial of "Full Spectrum CBD" capsules from "Fully-Activated" in Colorado, after a long and productive chat with its owner, Nick.

I will take a total of 90 mg daily in two-divided doses for my various Lyme-related neuropathies (and aches and pains), and then report back here. I am currently not on any other medication, so I make an excellent test subject.

We arrived at 90 mg in total daily, as it appears that an effective dose is one-half of your body weight daily (and I weigh 180 pounds). I will also take it on an empty stomach.

I did a lot of research in the last 24-hours and, needless to say, am very impressed by the potential of the cannabinoids! These suggest a whole new era in pain management, and I look forward to taking my first dose!

David

Have you been able to treat your lyme at all in hopes of treating the neuropathy?

Apollo 10-21-2018 09:09 AM

Quote:

Originally Posted by MCEC5 (Post 1268860)
Have you been able to treat your lyme at all in hopes of treating the neuropathy?


Yes, I have done a number of treatment programs over the years with 80% success in resolving the neuropathy.

David

DavidHC 10-21-2018 10:53 AM

Interesting and wonderful to hear. Now I'm curious: what have you done? It might be worth detailing some of it to help others on here, or perhaps you've already done that on another thread?

Also, on a side note, the salve from Fully Activated is excellent for more surface issues, including neuropathic itch and burning. It alleviates mine immediately.

heb1212 10-23-2018 09:44 AM

Quote:

Originally Posted by DavidHC (Post 1268890)
Interesting and wonderful to hear. Now I'm curious: what have you done? It might be worth detailing some of it to help others on here, or perhaps you've already done that on another thread?

Also, on a side note, the salve from Fully Activated is excellent for more surface issues, including neuropathic itch and burning. It alleviates mine immediately.

I’ve read and re-read this entire thread - thank you for your knowledge and experience. I’ve had severe body-wide neuropathy/neuralgia for 7 years. The doctors now feel it’s more of a centralized pain problem because they’ve never seen it so widespread. It’s unexplanable, except that I had a severe case of parvo virus b19 months before it began. I contemplated pursuing medical marijuana for years, and finally obtained my NYS license a couple months ago. I had such hope. I must say, though, I am almost wondering if it is making my pain worse. Could that be possible? I’m using less than prescribed, which is 5 mg 1:20 thc/cbd sublingual or capsule 2-4 times daily, both because of cost and the fact it makes me feel a little spaced out and tired. I’m still experimenting with what might work, but am wondering if anyone else has experienced an increase in pain? If anything, it does relax me a bit through my pain so it’s worth something. I continue to be an enigma - not a happy place.

DavidHC 10-24-2018 02:14 PM

I'm sorry you're suffering and conventional medicine hasn't been able to help so far. I'm in the same boat.

You raise a number of issues here. I'll try to address some of them and hope that helps.

First off, you will need to experiment yourself, since no one else can tell you what is helping or harming you except you, to the extent that that's possible, to the extent that you feel it. Cannabis might be making things worse for you, but only you can tell, and after some experimentation with dosage, strains and methods of administration.

Cannabis is very diverse and each strain has a variety of phytochemicals. Some strains are terrible for me, others work magic. Some make my symptoms worse because of the combination and/or ratios of cannabinoids and terpenes, others relieve them and give me great comfort. If you're using dry flower that's easy to know, but each oil or edible is also made from some specific flower with specific ratios and kinds of a variety of phytochemicals.

You're using 1:20 THC to CBD, so you might need to change that ratio, or maybe try another oil from another plant with other terpenes than the one you're using. You might increase the THC, or you might even try CBD isolate since THC and other cannabinoids could be what is causing you problems.

Regarding dosage, 5 mg is very low. In studies the doses administered are usually hundreds of mg for human adults. Sublingual is a good method of administration for bioavailability.

Hopefully this answers some of your questions.

heb1212 10-24-2018 06:04 PM

Quote:

Originally Posted by DavidHC (Post 1269009)
I'm sorry you're suffering and conventional medicine hasn't been able to help so far. I'm in the same boat.

You raise a number of issues here. I'll try to address some of them and hope that helps.

First off, you will need to experiment yourself, since no one else can tell you what is helping or harming you except you, to the extent that that's possible, to the extent that you feel it. Cannabis might be making things worse for you, but only you can tell, and after some experimentation with dosage, strains and methods of administration.

Cannabis is very diverse and each strain has a variety of phytochemicals. Some strains are terrible for me, others work magic. Some make my symptoms worse because of the combination and/or ratios of cannabinoids and terpenes, others relieve them and give me great comfort. If you're using dry flower that's easy to know, but each oil or edible is also made from some specific flower with specific ratios and kinds of a variety of phytochemicals.

You're using 1:20 THC to CBD, so you might need to change that ratio, or maybe try another oil from another plant with other terpenes than the one you're using. You might increase the THC, or you might even try CBD isolate since THC and other cannabinoids could be what is causing you problems.

Regarding dosage, 5 mg is very low. In studies the doses administered are usually hundreds of mg for human adults. Sublingual is a good method of administration for bioavailability.

Hopefully this answers some of your questions.

Thank you! Yes, your response is helpful - your posts have been sincere too. Living this has been a nightmare, not something anyone can understand, even the doctors - except the few others who have had the misfortune of such a bizarre experience. I have ZERO recreational marijuana experience and the NYS dispensary didn’t consult with me about strains - only ratios. I didn’t want to use the vape pen so I opted for the tincture, but maybe that would offer more options that could help. So far I think the 1:20 thc/cbd has done nothing. I really hope society, culture, politics change nationwide to allow medical marijuana at least, then maybe recreational. It seems like a reasonable alternative to opioids.

DavidHC 10-25-2018 01:34 PM

Thank you and I'm glad to hear it.

It's immensely difficult to live with this illness and all the many forms it takes. We need whatever we can get in the struggle.

Vaping flower might be an option for you if you want to experiment more with different strains and such things. It might also be worth increasing you dose if you're willing. Studies show you need much higher doses than that for pain management and pretty much any benefits. But you will know best what you're willing to do.

If you do vape, you won't need a vape pen, but a dry herb vaporizer, say like a Pax or even better an Arizer vaporizer like the Air or Solo. This will be easy to use for a newcomer. And it goes without saying that it's a reasonable alternative to opioids, a very reasonable one! :)

DavidHC 10-26-2018 11:01 AM

Some information on a recent study of CBD and neuropathic pain:

Cannabis pain relief without the 'high' | EurekAlert! Science News

The PubMed link: Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. - PubMed - NCBI

Apollo 10-26-2018 10:41 PM

Hi David!

I want to give you some early feedback regarding my first use of CBD.


First, I am using the "Fully Activated" company's CBD "Full Spectrum" capsules. I am taking a total of 90 mg daily (I was told to take half my weight of 180 pounds for a total daily mg dosage).


Here is an example on the website of the capsules I am taking:


Full Spectrum Capsules – Activated Shipping


After taking 90 mgs daily (60 mg at bedtime and 30 mg midday) for 72 hours (three days), I developed a faily severe headache centered in my forehead by the third day.


I also did not notice any pain relief (and, if anything, my overall pain seemed to be worse in addition to the headache). Indeed, the headache was bad enough I skipped today's dosing completely.


This was a disappointing start, and I would like to get what feedback you can offer (I will also call Nick on Monday).


Many thanks!


David

PNFUN 10-27-2018 10:03 PM

Concentration/percentage is a variable too
 
Thank you for this thread, which has prompted me to experiment again with CBD.

I've tried a number of different CBD/Hemp oil products and have been mostly disappointed (as in no benefit seen despite hundreds of dollars spent). However, I'm trying again, with higher doses in mind.

(GENETICS
I suspect genetics may play a role in sensitivity to CBD; for example, the 23&me test has some cannabinoid receptors tested for polymorphisms; but I've never seen genetics mentioned in any discussions or studies of CBD use).

DOSE
As other posts mention, some suggest the dose of 5mg for every 10lb (or, 1/2 your weight in miligrams).

CONCENTRATION
However, dosing is not so simple, as different products have different "percentages" (of CBD, CBDa, other stuff...).

For example, an Endoca oil looks appealing (organic, high 15%, etc.).
(I can't post the link yet...)

BUT, if I go for that 90mg daily dose, this $130 bottle will last me 16 days, costing about $8 per day (1500 mg / 90 mg/day = 16.67 days. $130 / 16.67 days = $7.79)

Not COMPLAINING (I'd rather put this stuff in my mouth than Lyrica, etc.), but just pointing out an example of the costs involved here, and the complicating factor of concentration.

Most of the CBD options out there are way over-priced. It's the Wild West with the cannabis industry, and greed and fraud are everywhere.

It seems it may take a while to titrate up (at least for me--I guess I was trying with far too little before) and figure out a useful dose.

(One more opinion: watch out for the miracle stories--"one drop and all my pain was GONE!"--they're likely B.S. and irrelevant to anyone else's experience.)

Apollo 10-28-2018 10:21 AM

Quote:

Originally Posted by PNFUN (Post 1269125)
Thank you for this thread, which has prompted me to experiment again with CBD.

I've tried a number of different CBD/Hemp oil products and have been mostly disappointed (as in no benefit seen despite hundreds of dollars spent). However, I'm trying again, with higher doses in mind.

(GENETICS
I suspect genetics may play a role in sensitivity to CBD; for example, the 23&me test has some cannabinoid receptors tested for polymorphisms; but I've never seen genetics mentioned in any discussions or studies of CBD use).

DOSE
As other posts mention, some suggest the dose of 5mg for every 10lb (or, 1/2 your weight in miligrams).

CONCENTRATION
However, dosing is not so simple, as different products have different "percentages" (of CBD, CBDa, other stuff...).

For example, an Endoca oil looks appealing (organic, high 15%, etc.).
(I can't post the link yet...)

BUT, if I go for that 90mg daily dose, this $130 bottle will last me 16 days, costing about $8 per day (1500 mg / 90 mg/day = 16.67 days. $130 / 16.67 days = $7.79)

Not COMPLAINING (I'd rather put this stuff in my mouth than Lyrica, etc.), but just pointing out an example of the costs involved here, and the complicating factor of concentration.

Most of the CBD options out there are way over-priced. It's the Wild West with the cannabis industry, and greed and fraud are everywhere.

It seems it may take a while to titrate up (at least for me--I guess I was trying with far too little before) and figure out a useful dose.

(One more opinion: watch out for the miracle stories--"one drop and all my pain was GONE!"--they're likely B.S. and irrelevant to anyone else's experience.)







If you read my post just above yours, you can learn about my initial experience using the "Full-Spectrum" CBD oil offered by the company "Fully Activated".

They seem to offer a good product, which "DAVIDHC" here on the forum agrees with (and he knows Nick, who owns the company and was a wealth of information when I called).

Regarding dose, like you it was suggested using a dosage in milligrams that is one-half my body weight. As I weigh 180 pounds, I thus started with 90 milligrams of the CBD oil in capsule form daily.

I started my test with CBD five days ago, and took a 60 mg capsule at bedtime and 30 mg capsule mid-day each day.

Unfortunately, I did not notice any pain relief, but rather developed a pretty bad headache by the third day (dosing at 90 mg daily) that was uncomfortable enough to stop the CBD.

I even seemed to have an enhancement of all of my body-wide pain, too!

I then stopped the capsules two days ago, and within 24-hours (yesterday) my headache was much better.

I am now waiting for feedback from "DAVIDHC" here on the forum, and will also call Nick at "Fully-Activated" on Monday for his feedback.

David

DavidHC 10-28-2018 12:53 PM

There's lots on here and unfortunately I don't have time to get into lots of details. But I'll make a few points and maybe they'll be helpful to you both.

For starters, I'm glad you're both experimenting. Cannabis is not a monolith and each strain is unique, this includes full spectrum products, each of which contains different ratios and kinds of cannabinoids and terpenes. If one doesn't work or doesn't give you the benefits you like, it doesn't mean they all won't work.

Price is really an issue, and so too is greed. There are companies that have compassionate pricing and then there is isolate. CBD isolate can get pretty cheap, as low as $10-15 per gram if you purchase larger quantities. I use isolate for this reason.

Dosage is complicated and everyone is different. There are some studies and everyone has an opinion. Ultimately you have to find what works for you. The dosage recommendations in the few studies out there are extremely high I find, partly because they focus on oral administration and that has reduced bioavailability, but I also can't speak to the quality of the CBD they're using. Scientific research into CBD is highly limited at this point but is increasing.

David, to your particular experience, it's not abnormal to experience headaches. I would do two things, decrease my dose and see how that goes, maybe even starting at a much lower dose and slowly working up. And second, I would try CBD isolate. You can try other full spectrum products too, but try isolate for sure and see how that goes. I know quite a few people who don't do well with full spectrum but thrive on isolate. You see, what you're taking has many different phytochemicals in it so there's no way to tell what the problem is. If you want to know whether CBD itself works for you, you will need to try isolate. Like I have said, I can't tolerate full spectrum myself when it comes to hemp and even most strains of MJ, but I do great when it comes to CBD isolate.

Apollo 10-28-2018 09:12 PM

Quote:

Originally Posted by DavidHC (Post 1269143)
There's lots on here and unfortunately I don't have time to get into lots of details. But I'll make a few points and maybe they'll be helpful to you both.

For starters, I'm glad you're both experimenting. Cannabis is not a monolith and each strain is unique, this includes full spectrum products, each of which contains different ratios and kinds of cannabinoids and terpenes. If one doesn't work or doesn't give you the benefits you like, it doesn't mean they all won't work.

Price is really an issue, and so too is greed. There are companies that have compassionate pricing and then there is isolate. CBD isolate can get pretty cheap, as low as $10-15 per gram if you purchase larger quantities. I use isolate for this reason.

Dosage is complicated and everyone is different. There are some studies and everyone has an opinion. Ultimately you have to find what works for you. The dosage recommendations in the few studies out there are extremely high I find, partly because they focus on oral administration and that has reduced bioavailability, but I also can't speak to the quality of the CBD they're using. Scientific research into CBD is highly limited at this point but is increasing.

David, to your particular experience, it's not abnormal to experience headaches. I would do two things, decrease my dose and see how that goes, maybe even starting at a much lower dose and slowly working up. And second, I would try CBD isolate. You can try other full spectrum products too, but try isolate for sure and see how that goes. I know quite a few people who don't do well with full spectrum but thrive on isolate. You see, what you're taking has many different phytochemicals in it so there's no way to tell what the problem is. If you want to know whether CBD itself works for you, you will need to try isolate. Like I have said, I can't tolerate full spectrum myself when it comes to hemp and even most strains of MJ, but I do great when it comes to CBD isolate.






Many thanks for your insights, David, and I will consider your suggestion regarding using "Isolate" (instead of my current "Full-Spectrum") after I talk with Nick on Monday.

However, from what I have read, it sure sounds like the "full-spectrum" provides the synergistic balance of compounds that really make CBD work.

So, do I try "Isolate" at 90 mgs per day, or stick with my current "full-spectrum" but at a lower dose? And, if a lower dose, then what dose?

It is never easy (grin)!

Again, David, thank you!

David

DavidHC 10-29-2018 01:24 PM

You're welcome. It takes time and experimentation to figure out what works for you.

Yes, you're right that full spectrum has what's called an entourage effect and can be more effective, at least according to some initial limited studies. However, it can also lead to bad reactions in some people, including myself, because it's not just CBD but a host of other phytochemicals any one of which or the combination of which could be the culprit. If you're having issues with full spectrum, then it's really irrelevant how effective it can be, since you can't tolerate it in the first place. The thing to do in such cases, if you want to know whether CBD works for you, is to isolate the variables. CBD isolate allows you to do this.

90 mg a day is not a lot to begin with, but it is if you're taking it all at once. Maybe try 30 mg 3 times a day. If that's what you're already doing, try 10 mg or 20 spread out in the day. Again, your best bet is to experiment with various doses, kinds of full spectrum from different companies and to try isolate. Isolate from Fully Activated is excellent, clean and potent, not to mention well priced.

Good luck!

Apollo 10-29-2018 05:53 PM

Quote:

Originally Posted by DavidHC (Post 1269173)
You're welcome. It takes time and experimentation to figure out what works for you.

Yes, you're right that full spectrum has what's called an entourage effect and can be more effective, at least according to some initial limited studies. However, it can also lead to bad reactions in some people, including myself, because it's not just CBD but a host of other phytochemicals any one of which or the combination of which could be the culprit. If you're having issues with full spectrum, then it's really irrelevant how effective it can be, since you can't tolerate it in the first place. The thing to do in such cases, if you want to know whether CBD works for you, is to isolate the variables. CBD isolate allows you to do this.

90 mg a day is not a lot to begin with, but it is if you're taking it all at once. Maybe try 30 mg 3 times a day. If that's what you're already doing, try 10 mg or 20 spread out in the day. Again, your best bet is to experiment with various doses, kinds of full spectrum from different companies and to try isolate. Isolate from Fully Activated is excellent, clean and potent, not to mention well priced.

Good luck!






Hi David!

I called Nick at "Fully Activated" this afternoon, and the first thing he told me was that he never had any of his customers ever report getting a headache!

Hmmmmmm .... now my BS alarm is going off.

I also asked him about using "Isolate" CBD instead of "Full-Spectrum", and he said that should not make a difference (not enough THC to affect anything, and the other stuff would not cause a headache).

Well, I DID have a clear effect from the CBD (i.e. headache and enhanced body pain) that got better when I stopped, so I now doubt what Nick tells me.

I will try just taking the 30 mg capsule once daily midday and see what happens. If the headaches don't return after a week, then I will bump that up to 60 mg midday.

Finally, if the headaches still don't return at a dose of 60 mg daily after one week, then I will try the 90 mg again daily (in divided doses).

Thoughts, David?

Disappointed in Atlanta

DavidHC 10-29-2018 07:20 PM

Hi David,

I'm not sure what else I can say that will be helpful in addition to what I've already said, but I can try.

Nick is not an expert on this stuff. He knows somethings like others, but he's a business man. He is likely not lying about all this, and I suspect he's not given my familiarity with him, so perhaps none of his customers have reported such side effects to him. But you can just go on the CBD subReddit and see how there are a fair number of people who report headaches and others side effects, especially when it comes to full spectrum oils. There you'll also see how there is a sizable minority who cannot tolerate full spectrum products.

It may not be the THC, or even other cannabinoids, or even the many terpenes, but some combination of them and only when interacting with you in particular. There's no way for Nick to know all this. Such things are immensely complex and there is little research on it and the endocannabinoid system. You should listen to your body in such situations and experiment as much as you can, controlling as many variables as possible. This is what I do with anything new that I introduce.

My advice remains the same to try lower doses that are spread out throughout the day, to try isolate rather than full spectrum, to try other full spectrum strains/products from other companies, and to give it some time. It took me months before I fully figured out what works for me, and I had to throw out somethings or give them away because I couldn't tolerate them. And I know now that I do not tolerate full spectrum but do great on isolate. But even now I can't say I can't tolerate all full spectrum strains, since I've only tried a few. I may even try more in the future, but I'm happy with the effectiveness of isolate for now.

I hope this helps and that you experiment more and that things improve for you!

Apollo 10-31-2018 11:19 PM

Well, it is several days since my last message just above, and I tried taking a single "Fully-Activated" brand 30 mg CBD capsule again this afternoon.

Unfortunately, within 30 minutes I had an aching head again!

CBD sounds promising, but in my case at least my trial was anything but!

I will be sending Nick at "Fully Activated" a message Thursday, offering to return my essentially-unused capsules for a full refund of the $145.00 I paid.

If he resists, then I will simply request a charge-back on my credit card.

I am really sorry that this did not work, and also somewhat surprised when he told me the other day on the phone that he has never heard of even one of their customers getting a headache when using CBD.

Well, then I must be that one customer.

David F.

DavidHC 11-01-2018 10:20 AM

David,

I'm sorry you got a headache again. It's unfortunate.

I'm not sure what they return policy is but you can ask them. I'm not sure many companies will accept returns and provide refunds on used products. I've never tried this myself. But you can ask Fully Activated about that.

Of course it's up to you, but my position has been the same all along that if you want to know whether CBD works for you, it will require trying more than one product, given the vast differences from plant to plant and so from one full spectrum product to another, which is a product that has much more than CBD in it. In the majority of CBD studies they use CBD isolate as you would any medication, since that's the only way you can isolate the relevant variable.

Whatever you decide, I hope you continue to experience improvement with your condition! :)



Quote:

Originally Posted by Apollo (Post 1269251)
Well, it is several days since my last message just above, and I tried taking a single "Fully-Activated" brand 30 mg CBD capsule again this afternoon.

Unfortunately, within 30 minutes I had an aching head again!

CBD sounds promising, but in my case at least my trial was anything but!

I will be sending Nick at "Fully Activated" a message Thursday, offering to return my essentially-unused capsules for a full refund of the $145.00 I paid.

If he resists, then I will simply request a charge-back on my credit card.

I am really sorry that this did not work, and also somewhat surprised when he told me the other day on the phone that he has never heard of even one of their customers getting a headache when using CBD.

Well, then I must be that one customer.

David F.


Apollo 11-01-2018 10:27 AM

Thanks for your reply, David.

Well, on the one hand Nick states that he has never had a report of anyone being hurt (literally in my case) by their product. If that is the case and I was, then I must have received a bad batch of it.

Logically, there is no other option, and I can assure you that I will be receving a refund either as a credit back to my account, or a charge-back to my card.

Thanks again for your insights, David!

Apollo 11-02-2018 11:39 AM

Just a quick update to say that Nick at "Fully Activated' stood behind his product and issued a refund!

MelodyL 12-12-2018 05:54 PM

David:

Hi. My husband has had idiopathic peripheral neuropathy for 30 years. We live in NYC and he received his medical marijuana card last week. Alas we can't afford the product. He does however use the CBD Oil. We got the gummy bears. 250 strength. He said "I need the 500". So tomorrow I will go to the Vape Store and get the bag of gummies (or should I get tincture)? He is also on Tramadol but we would like to have him get off drugs. That would be a blessing but until we find the correct kind of cbd oil, well Tramadol is a godsend.

What do you think? Should I purchase the gummies, or the tincture. What happens when one uses the 500? Does it relax you? I have muscle spasms and the only thing that helps is Theraworx. Now that product is a miracle.

Your input is most welcome, believe me. Thank you in advance

Melody

surfer00 12-13-2018 05:27 PM

Hi all, long time, no visit.
I was just researching this subject the other day. One time I read the owner of Charlottes Web, the famous marijuana strain that helped the little girl with seizures (made all the news), say that cbd alone really didn't achieve much and it needed thc for benefits. I can't find the quote anywhere.

I'm glad some here are finding relief from CBD. I need to look into it again. I use Thc dominant marijuana every night for pain and sleeping, but would like some relief during the day. I'm on Lyrica, which actually seems to help, but it leaves me groggy and kind of dumb, if you know what I mean.

I have to admit that the wide-spread sales and marketing of CBD lately has me put-off. Almost a fad-like vibe to it, with claims that it helps with just about anything that you might suffer with. I wish they would do proper testing for everyone and sort out the real from the fables. Until then, I'll keep an eye on this thread and see how others are doing on it.

MelodyL 12-14-2018 09:39 AM

I bought the tincture. It helped Alan's neuropathy
 
Hi David and everybody. I have been reading with interest all the posts about cbd and salves and creams. Yesterday I went to the Vape Store around the corner from my home. I purchased the CBD tincture 500 for $40.00. Last night I took 4 drops and slept for 4 hours. I awoke at 2:30 and took 3 more. Should have taken another 4 or even 5. I watched videos before bedtime on dosing and cbd and it seems that less is a stimulant and more is a sleep agent.
Also, I'm reading about the health benefits of the salve for peripheral neuropathy so we did an experiment. I had no salve but because I had the tincture, I put some drops between Alan's toes (bad neuropathy). Well, it's been two hours and no pain. Can't believe it.

I'm going back today (just to do research and see what they have). l believe, if this product does what it's supposed to do, maybe, just maybe, it might relieve, not only his neuropathy but other auto immune issues as well. Like his full blown psoriasis. Nothing to lose and it seems to be helping his neuropathy so that alone is a miracle because nothing works. He's had PN for over 30 years and no one knows why. Personally I believe that when he was 32 he got a fever of unknown origin and the doctors said it was some kind of virus. I believe it was Epstein Barre. It wreaks havoc in the body for years. It got activated and for 30 or so years my husband has had such pain and his health has declined.

Never knew about cbd oil. What is it some big secret in the health industry. They push pills and drugs but not this which actually helps people.

And for myself, I am taking it every day. Two drops in the daytime and 5 drops at night. Starting today. I want to help my eye (that had the stroke) and I want to protect my good eye. What the heck do I have to lose?

So if anyone cares to share info I'd love a response.

Thanks much

Melody

DavidHC 12-16-2018 02:58 PM

Hi all,

I haven't been on here checking much for a while. I just saw the posts.


Apollo/David, good things worked out for you on getting your refund.


Melody, it's great that you've found CBD to be so helpful. I'm not surprised. CBD or cannabis salve as a whole does wonders for me and many others I know, including people on here. You should definitely try some quality salve. I use the one from Fully Activated and it works great. I know at least two other people on here get great relief from it. Obviously putting some of the tincture oil on your skin can help too.

You asked about tincture vs gummies/candy I think. The former is much better in terms of bioavailability and immediate impact as it makes its way immediately to the blood stream when administered in sublingual method. You can ingest CBD if you like and it will have benefits, even perhaps benefits for the gut that tincture straight to the blood stream won't, I don't know given the lack of research, but much less will get to you that way, about half the amount in terms of bioavailability. So sublingual use is more cost effective.

I would just make sure it's 3rd party lab tested for potency and residual solvents. This is really important. Online retailers are the best and by far the most affordable, and there are many of them.

I'm not sure if I answered all your questions, but I'll check this thread more regularly now if you have more questions. :)


surfer00, CBD or cannabis as a whole tends to have that reputation because it works centrally on the body as well as in various areas. What I mean is that it systematically reduces inflammation that effects all aspects of the body, so stress, anxiety, skin conditions, blood pressure and so on. But you're right that studies, not just anecdotal reports, show that cannabinoids (and even terpenes) together can be more effective than just single cannabinoids, at least for some people and conditions. THC itself definitely has medicinal benefits. Most hemp derived CBD will also have some amounts of THC and other cannabinoids as well as other phytocannabinoids. Lab tests for potency should reveal this. I use some THC some nights when the insomnia is bad and use CBD isolate during the day.

MelodyL 12-17-2018 08:57 PM

David:
Last night I did six drops under the tongue and it did really nothing. But it helped the night before. I really don't understand this cbd thing. And the cream I bought (the small little jar), was $60 but I paid $40. I would never buy such a small jar again. Sure, it works on my bad arthritic hand but it doesn't last. Does the Fully Activated Salve work better?

Thanks David
P.S. I don't know how people are able to afford medical marijuana. It's so expensive. Someone told me that the powers that be are trying to pass a bill that would make insurance companies pay for medical marijuana. Do you think this will happen?

DavidHC 12-21-2018 02:01 PM

The way in which cannabinoids, including CBD, work on your endocannabinoid system is complex and not well understood due to a lack of research. This is mostly because of the moronic and politically motivated prohibition in the USA. It has affected the rest of the world and so global research too over the last century. More and more research is being conducting with each passing year, and the 2018 farm bill that passed yesterday made hemp cultivation federally legal. This was a milestone.

There could be a number of reason why you had this experience. A simple answer is that over time you build up tolerance and need to increase your dosage. It also sounds like you're taking a very low dose. I don't know what concentration you're taking, since how many drops you take tells me nothing really, but my guess is the dose you're taking is very low and not an effective dose. We measure CBD oil consumption by mg since concentrations vary. An effective adult dose can be hundreds of mg.

Another possible reason you experienced nothing the second time around is more complex and has to do with your endocannabinoid system and the state it is in. CBD and other cannabinoids interact with your body, including your immune system, in complex ways and there could be many reasons why a given dose is effective one time and not another (e.g., degree of inflammation is a significant one). So it's complex unfortunately and there's no easy answer. I know it can be frustrating and confusing but the only thing I can say is it might be worth experimenting to see what works for you.

I know, it's all so expensive. But yes, like any medicine it only lasts so long and needs to be re-administered. You can try the salve from Fully Activated if you like. It works well for many people including myself, but any full spectrum CBD salve should help as long as it's from a trustworthy company. Fully Activated is one such company. I can't speak to any other US companies since I haven't used any others from the states. It's worth a try for sure.

If price is an issue, you can always try CBD isolate and then make your own tinctures. It's not as effective for some people because it lacks the so called entourage effect, but it can be really cheap, as little as $20 a gram. Cannabis prices are too high right now and many CBD companies are price gouging. But there are some good options out there. If you're in a legal state, you can grow your own too. :)

What those criminal American insurance companies will do is as much a mystery to me as it is to you!



[I][/I]
Quote:

Originally Posted by MelodyL (Post 1270630)
David:
Last night I did six drops under the tongue and it did really nothing. But it helped the night before. I really don't understand this cbd thing. And the cream I bought (the small little jar), was $60 but I paid $40. I would never buy such a small jar again. Sure, it works on my bad arthritic hand but it doesn't last. Does the Fully Activated Salve work better?

Thanks David
P.S. I don't know how people are able to afford medical marijuana. It's so expensive. Someone told me that the powers that be are trying to pass a bill that would make insurance companies pay for medical marijuana. Do you think this will happen?


IPN1967 12-21-2018 10:07 PM

Quote:

Originally Posted by Apollo (Post 1268889)
Yes, I have done a number of treatment programs over the years with 80% success in resolving the neuropathy.

David

David - You mentioned in an early port that you have done a number of programs over the years with 80% success. Can you please share these programs and which ones yielded the best results?

Thanks

stulerner 01-18-2019 12:03 AM

CBD for PN
 
I have used CBD from hemp and from marijuana with zero benefit. Tried different brands and dosages, all to no avail. Unfortunately, there is no independent research about CBD usage, dosage, etc. Here in Nevada CBD and THC have been legal for years and is somewhat regulated for cleanliness and purity, but that does not mean it works. It has become a rip-off industry. Here is a good example: I have tried high dose CBD (1,000 mg/ dropper to no avail). A friend thought he would help me by buying CBD. The product he purchased states clearly:
3mg CBD/dropper!!!. I believe that the business success of the CBD industry tells
us there is an enormous amount of pain in the country that we will try anything. And the prices are outrageous.

DavidHC 01-18-2019 01:11 PM

I'm sorry CBD hasn't worked for you and there are certainly shady dealers out there as with anything that involves health+money. But this doesn't mean it doesn't work for everyone. In fact, many, most, experience some relief and the limited studies show this when it comes to cannabis as a whole and specific cannabinoids including CBD. I know 2 people myself that didn't find it helped and who were disappointed, but a few dozen more who did. Often CBD combined with THC and other cannabinoids can be more helpful, but again it varies from individual to individual.

The 3mg per dropper is a joke though! Studies show we need far higher doses for it to actually be effective especially for chronic pain. The prices are horrible too, agreed. But there are good companies with low markups and discounts for low income people suffering. Lazarus Naturals is one example. They have a special discount program for those who can't afford it but need it.

In the end, each person can make up their own mind and see if it's worth trying. For me, it helps in a number of ways and I'm grateful for that. We have so few options left to us and really none when it comes to conventional medicine, or none that are not detrimental to our health in other ways, so it made sense to me to give it try.

MelodyL 01-19-2019 11:35 AM

Hi. I have just applied for the discount on Lazarus Naturals. I attached a letter from Alan's doctor about his severe neuropathy. I also sent them a message explaining about Alan. Lets hope this works.

Alan has enjoyed great results from the cbd oil that we get from around the corner in a Vape Store. My last purchase was for the little bottle of 1000. I give him 12 drops under the tongue. Seems to do the trick but on an especially bad night I give him a bit more a few hours later.

I'm not sure about the dosing or the strength I should be buying. On the Lazarus naturals website, what should I buy? And how many drops? I know everyone is different but this is still confusing to me.

Thanks so much if you can clear this up a bit for me. Alan really could use some help because this poor man falls and has many disabilities.

Thanks so much, Melody

MelodyL 01-22-2019 10:08 AM

David:

I want to thank you personally for suggesting Lazarus Naturals. Alan was accepted to their discount program. All I had to do was upload a letter from his doctor attesting to his diagnosis of Neuropathy (he's had it for 35 years).

I received their approval first thing this morning. I went to their site and purchased the balm and the tincture of CBD. All for a very reasonable amount. Much less than what I would pay around the corner at the Vape shop. omg. much less.

So I shall update on how he does.

Sincerely, Melody

DavidHC 01-22-2019 02:02 PM

Hi Melody,

I'm glad it worked out for you and Alan. I hope CBD continues to help him. Topicals and tincture are a great combination and it's wonderful that Lazarus accepted your application.

I would recommend keeping a journal of what dose you use. Begin with a low dose and slowly increase it, keeping a record of how many mg (not how many drops) you give him. This way you can find what they call the lowest effective dose. You may need to adjust and increase the dose depending on the severity of his symptoms and if he builds up tolerance which happens. But this way you can get a good idea what he needs.

I always buy the strongest concentration I can find because it's the cheapest per mg. You can then estimate how many mg you want to give him using the dropper. The concentration and number of drops has nothing to do with the proper dosage and you can plan accordingly.




Quote:

Originally Posted by MelodyL (Post 1271597)
David:

I want to thank you personally for suggesting Lazarus Naturals. Alan was accepted to their discount program. All I had to do was upload a letter from his doctor attesting to his diagnosis of Neuropathy (he's had it for 35 years).

I received their approval first thing this morning. I went to their site and purchased the balm and the tincture of CBD. All for a very reasonable amount. Much less than what I would pay around the corner at the Vape shop. omg. much less.

So I shall update on how he does.

Sincerely, Melody


MelodyL 01-23-2019 09:54 AM

Hi. What do you mean the number of drops have nothing to do with the dosage? How do I know what I''m giving him.. I do not understand this at all. I am so new to this cbd thing I can't tell you. When I give him the cbd oil, I use a dropperfull. I do not know how much cbd this is.

I am using the 1000 bottle now (that I bought from around the corner). When I get the shipment from Larazus naturals (I bought the high potency 750 bottle), do I give him the same dropperful?

Please help me. I don't know low dosages from high dosages.

Thanks much. Melody

DavidHC 01-23-2019 11:04 AM

There are different concentrations. First ask yourself how many ml of oil the CBD is mixed into. If you have a 30ml bottle with 1000mg of CBD in it, 1ml will have 33mg of CBD in it. A full dropper typically is 1ml with room for 20 drops, meaning each drop is .05ml with 1.65mg of CBD. The same size bottle containing 30ml of oil with 750mg of CBD mixed into it will have a different dose of CBD in a full dropper and in each drop. So you don't want to be counting how much you give him based on droppers or drops but mg. 750mg of CBD in a 30ml bottle of oil will only have 25mg per full dropper and 1.25mg of CBD per drop.

Edit: To be very clear, you need to divide the mg of CBD in the bottle by the ml of oil (e.g., 1000mg divided by 30 ml = 33.33mg in each ml of oil). Remember a full dropper is approximately 1ml and has approximately 20 drops.


Quote:

Originally Posted by MelodyL (Post 1271635)
Hi. What do you mean the number of drops have nothing to do with the dosage? How do I know what I''m giving him.. I do not understand this at all. I am so new to this cbd thing I can't tell you. When I give him the cbd oil, I use a dropperfull. I do not know how much cbd this is.

I am using the 1000 bottle now (that I bought from around the corner). When I get the shipment from Larazus naturals (I bought the high potency 750 bottle), do I give him the same dropperful?

Please help me. I don't know low dosages from high dosages.

Thanks much. Melody


MelodyL 01-24-2019 10:26 AM

I wish I had paid attention in school in math. I'm doomed. But I'll survive. Let's hope Alan does too. rofl.

Melody


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